The use of Trichuris suis and other helminth therapies to treat Crohn’s disease
The use of Trichuris suis and other helminth therapies to treat Crohn’s disease
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使用猪鞭虫和其他蠕虫疗法治疗克罗恩病
DOI：
10.1007/s00436-006-0416-4
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发表时间：
2007
影响因子：
2
通讯作者：
B. Fried
中科院分区：
文献类型：
--
作者：
A. Reddy;B. Fried
胃肠道（GI）线虫感染在全球范围内普遍存在，尽管抗蠕虫药物被认为是安全、有效和广泛可用的。在这篇综述中，我们强调了通过临床使用猪鞭虫和其他蠕虫治疗克罗恩病（CD）可能实现的潜在治疗益处。长寿命的蠕虫寄生虫在下调宿主免疫力、保护自身免于消除以及最小化严重的病理性宿主变化方面具有显著的能力。这篇综述总结了什么是已知的潜在机制，可以解释所观察到的模式，在人类治疗CD蠕虫。免疫系统的Th2臂被强调为在宿主免疫系统和GI线虫感染之间的关联中最重要的组分。虽然胃肠道线虫感染在人类引起显着的发病率和死亡率，这些蠕虫可能赋予的保护机制的存在和性质仍然在很大程度上不清楚。
Infections with gastrointestinal (GI) nematodes are prevalent worldwide, despite the fact that anti-helminthic medications are regarded as safe, efficient, and widely available globally. In this review, we highlight the potential therapeutic benefits that may be realized through the clinical use of Trichuris suis and other helminths for Crohn’s disease (CD). Long-lived helminthic parasites are remarkable in their ability to down-regulate host immunity, protecting themselves from elimination, and also minimize severe pathological host changes. This review summarizes what is known about the underlying mechanisms that may account for the observed patterns in humans treated with helminths for CD. The Th2 arm of the immune system is emphasized as a component of primary importance in the association between the host immune system and GI nematode infections. Although GI nematode infections in humans cause significant morbidity and mortality, the existence and nature of protective mechanisms these helminths may confer remain largely unclear.
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影响因子：
4.4
作者：
M. N. Ince;D. Elliott;Tommy Setiawan;A. Blum;A. Metwali;Ying Wang;J. Urban;J. Weinstock
通讯作者：
M. N. Ince;D. Elliott;Tommy Setiawan;A. Blum;A. Metwali;Ying Wang;J. Urban;J. Weinstock
DOI：
10.1152/ajpgi.00049.2002
发表时间：
2003-03-01
影响因子：
4.5
作者：
Elliott, DE;Li, J;Weinstock, JV
通讯作者：
Weinstock, JV
影响因子：
2.5
作者：
Elliott,DavidE;Summers,RobertW;Weinstock,JoelV
通讯作者：
Weinstock,JoelV
影响因子：
29.4
作者：
Keates, AC;Castagliuolo, I;Kelly, CP
通讯作者：
Kelly, CP
影响因子：
4.8
作者：
Elliott, DE;Urban, JF;Weinstock, JV
通讯作者：
Weinstock, JV