PDMS microchannel fabrication technique based on microwire-molding
PDMS microchannel fabrication technique based on microwire-molding
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DOI：
10.1007/s11434-008-0528-6
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发表时间：
2008-12-01
影响因子：
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通讯作者：
Wu YunPeng
中科院分区：
文献类型：
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作者：
Jia YueFei;Jiang JiaHuan;Wu YunPeng
微流道是微流控芯片的基本功能部件，其构建技术的每一步进步都受到国内外的关注。本文提出了一种不复杂但灵活的微流通道制造方法。该方法主要利用聚二甲基硅氧烷（PDMS）的常规成型能力和广泛的商业微丝作为模板。我们已经制造出了一些具有不同拓扑形状的传统类型的微通道，作为演示这种灵活的制造路线的示例，该路线不依赖于光刻或微机电系统（MEMS）技术的严格要求。导线的光滑表面、高强度和高柔韧性使得创建多种类型的二维或三维微通道或通道阵列的拓扑结构成为可能。如果采取适当的措施，在PDMS中形成的微通道的横截面的几何形状与嵌入微丝的横截面的几何形状相反，并且具有高保真度。此外，这种微通道制造工艺可以轻松地将金属线的导电性和低电阻率结合起来，以创建适合微通道中液体的电磁控制或温度调节的微流装置。此外，提供了一些初步的光学分析以观察由此形成的圆形微通道。基于这种成型策略，我们甚至制作了一些功能性微流应用的原型，例如微螺线管芯片和温度控制小工具。并且在交叉通道中形成液滴的实验进一步证实了这种柔性微通道形成技术的可行性和适用性。
Micro-flow channel is basic functional component of microfluidic chip, and every step-forward of its construction technique has been receiving concern all over the world. This article presents a notcomplicated but flexible method for fabrication of micro-flow channels. This method mainly utilizes the conventional molding capability of polydimethylsiloxane (PDMS) and widespread commercial microwires as templates. We have fabricated out some conventional types of microchannels with different topological shapes, as examples for the demonstration of this flexible fabrication route which was not dependent on the stringent demands of photolithographical or microelectromechanical system (MEMS) techniques. The smooth surface, high-intensity, and high flexibility of the wires made it possible to create many types of topological structures of the two-dimensional or three-dimensional microchannel or channel array. The geometric shape of the cross-section of thus forming microchannel in PDMS was the negative of that of embedded-in microwire, in high-fidelity if suitable measures were taken. Moreover, such a microchannel fabrication process can easily integrate the conductivity and low resistivity of the metal wire to create micro-flow devices that are suitable for the electromagnetic control of liquid or the temperature regulation in the microchannel. Furthermore some preliminary optical analysis was provided for the observation of thus forming rounded microchannel. Based on this molding strategy, we even made some prototypes for functional microflow application, such as microsolenoids chip and temperature control gadgets. And an experiment of forming a droplet in the cross channel further confirmed the feasibility and applicability of this flexible microchannel forming technique.