Amplification of cyclin genes in colorectal carcinomas.
Amplification of cyclin genes in colorectal carcinomas.
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DOI：
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发表时间：
1993-05
期刊：
影响因子：
11.2
通讯作者：
F. Leach;S. Elledge;C. Sherr;J. Willson;S. Markowitz;K. Kinzler;B. Vogelstein
中科院分区：
文献类型：
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作者：
F. Leach;S. Elledge;C. Sherr;J. Willson;S. Markowitz;K. Kinzler;B. Vogelstein
在47个结直肠癌细胞系中检测了细胞周期蛋白基因的遗传状态。发现细胞周期蛋白D2在一个肿瘤中扩增，而细胞周期蛋白E在另一个肿瘤中扩增。在这两种情况下，扩增的细胞周期蛋白基因在蛋白质或mRNA水平上都过表达。Cyclin D1先前在乳腺癌和其他肿瘤中被放大，但在这些癌症中没有被放大。这些数据表明，多种细胞周期蛋白基因可以在人类肿瘤发生中发挥作用，并且细胞周期蛋白D2和E在结直肠肿瘤中特别重要。
The genetic status of cyclin genes was examined in a panel of 47 colorectal carcinoma cell lines. Cyclin D2 was found to be amplified in one tumor and cyclin E in another. In each of the two cases, the amplified cyclin gene was overexpressed at the protein or mRNA level. Cyclin D1, previously shown to be amplified in breast and other tumors, was not amplified in these cancers. These data suggest that a variety of cyclin genes can play a role in human tumorigenesis and that cyclins D2 and E are particularly important in a subset of colorectal neoplasms.