Simultaneous Recognition of Allogeneic MHC and Cognate Autoantigen by Autoreactive T Cells in Transplant Rejection.
Simultaneous Recognition of Allogeneic MHC and Cognate Autoantigen by Autoreactive T Cells in Transplant Rejection.
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DOI：
10.4049/jimmunol.1700856
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发表时间：
2018-02-15
期刊：
影响因子：
--
通讯作者：
Nakayama M
中科院分区：
文献类型：
--
作者：
Burrack AL;Landry LG;Siebert J;Coulombe M;Gill RG;Nakayama M
The autoimmune condition is a primary obstacle to inducing tolerance in type 1 diabetes patients receiving allogeneic pancreas transplants. It is unknown how autoreactive T cells that recognize self MHC molecules contribute to MHC-disparate allograft rejection. In this report, we show the presence and accumulation of dual-reactive, i.e. auto- and allo-reactive, T cells in C3H islet allografts that were transplanted into autoimmune diabetic NOD mice. Using high-throughput sequencing, we discovered that T cells prevalent in allografts share identical T cell receptors (TCRs) with autoreactive T cells present in pancreatic islets. T cells expressing TCRs that are enriched in allograft lesions recognized C3H MHC molecules, and five of six cell lines expressing these TCRs were also reactive to NOD islet cells. These results reveal the presence of autoreactive T cells that mediate cross-reactive alloreactivity, and indicate a requirement for regulating such dual-reactive T cells in tissue replacement therapies given to autoimmune individuals.
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DOI：
10.1111/j.1600-6143.2012.04341.x
发表时间：
2013-02
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
--
作者：
Lowe MC;Badell IR;Turner AP;Thompson PW;Leopardi FV;Strobert EA;Larsen CP;Kirk AD
通讯作者：
Kirk AD
DOI：
10.1016/s0340-904x(79)80056-1
发表时间：
1979-01-01
期刊：
ZEITSCHRIFT FUR IMMUNITATSFORSCHUNG-IMMUNOBIOLOGY
影响因子：
--
作者：
DROGE, W
通讯作者：
DROGE, W
影响因子：
8.8
作者：
Kandaswamy, R.;Stock, P. G.;Kasiske, B. L.
通讯作者：
Kasiske, B. L.
影响因子：
4.4
作者：
Kupfer, TM;Crawford, ML;Gill, RG
通讯作者：
Gill, RG
影响因子：
7.7
作者：
Michels, Aaron W.;Landry, Laurie G.;Nakayama, Maki
通讯作者：
Nakayama, Maki