Impaired face recognition is associated with abnormal gray matter volume in the posterior cingulate cortex in congenital amusia
Impaired face recognition is associated with abnormal gray matter volume in the posterior cingulate cortex in congenital amusia
复制标题
面部识别受损与先天性失乐症后扣带皮层灰质体积异常有关
DOI：
10.1016/j.neuropsychologia.2021.107833
复制
发表时间：
2021-03-26
期刊：
影响因子：
2.6
通讯作者：
Wu, Daxing
中科院分区：
文献类型：
--
作者：
Jin, Zhishuai;Lu, Xuejing;Wu, Daxing
先天性失音症是一种神经发育障碍，主要表现为音高辨别和音高记忆障碍。有趣的是，据报道，先天性失音症患者也表现出面部识别缺陷（面孔失认症）。对这种共病的一种解释是，音高识别和面部识别的神经基质可能是相似的。为了验证这一假设，使用剑桥面部记忆测试（CFMT）评估了患有和不患有先天性失音症的参与者的面部识别能力，并通过基于体素的形态测定法（VBM）确定了灰质体积。不出所料，与对照组相比，失音患者在CFMT测试中的表现更差，在颞中回（MTG）、颞上回（STG）和右半球后扣带皮层（PCC）的灰质体积（GMV）减少。此外，相关分析表明，CFMT评分与所有参与者的MTG、STG和PCC GMV呈正相关，而每组的单独分析发现CFMT评分与音乐中的PCC GMV呈正相关。这些发现表明，人脸识别与人类大脑中广泛分布的微观结构网络有关，PCC在音乐中的音高识别和人脸识别中都起着重要作用。此外，神经发育障碍如先天性失音症和面孔失认症可能具有共同的神经基质。
Congenital amusia is as a neurodevelopment disorder primarily defined by impairment in pitch discrimination and pitch memory. Interestingly, it has been reported that individuals with congenital amusia also exhibit deficits in face recognition (prosopagnosia). One explanation of such comorbidity is that the neural substrates of pitch recognition and face recognition may be similar. To test this hypothesis, face recognition ability was assessed using the Cambridge Face Memory Test (CFMT) and gray matter volume was determined through voxelbased morphometry (VBM) among participants with and without congenital amusia. As expected, participants with amusia performed worse on the CFMT test and showed reduced gray matter volume (GMV) in the middle temporal gyrus (MTG), the superior temporal gyrus (STG), and the posterior cingulate cortex (PCC) in the right hemisphere, when compared with matched controls. Furthermore, correlation analyses demonstrated that the CFMT score was positively related to MTG, STG, and PCC GMV in all participants, while separate analyses of each group found a positive correlation of CFMT score and PCC GMV in amusics. These findings suggest that face recognition is associated with a widely distributed microstructural network in the human brain and the PCC plays an important role in both pitch recognition and face recognition in amusics. In addition, neurodevelopmental disorders such as congenital amusia and prosopagnosia may share a common neural substrate.