SEVERE ALCOHOL-INTOXICATION - A STUDY OF 204 CONSECUTIVE PATIENTS
SEVERE ALCOHOL-INTOXICATION - A STUDY OF 204 CONSECUTIVE PATIENTS
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DOI：
10.3109/15563658909000358
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发表时间：
1989-01-01
期刊：
影响因子：
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通讯作者：
BOUTIETTE, L
中科院分区：
文献类型：
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作者：
MINION, GE;SLOVIS, CM;BOUTIETTE, L
我们报告了对成人医疗急诊科连续 204 名血液酒精浓度 (BAC) 超过 400 毫克/分升的患者进行的五个月回顾性分析。平均 BAC 为 467 mg/dl，范围为 400-719 mg/dl。 153 名患者 (75%) 的 BAC 为 400-500 mg/dl，47 名患者 (23%) 的 BAC 为 500-600 mg/dl，4 名患者 (2%) 的 BAC 大于 600 mg/dl。 88% 的患者在询问时能够认清人物、地点和时间，12% 的患者迷失方向或对有害刺激无反应。 BAC 大于 600 mg/dl 的 4 名患者最初没有警觉和定向，无反应的患者中只有 8 名 BAC 低于 500 mg/dl (p < .001)。 16 名患者（8%）入院。其中三人因推测是由于乙醇而持续无反应而入院，另外十三人则因同时存在的医疗状况而入院。 BAC 和生命体征异常之间没有显着关联。在本系列中，400-500 mg/dl 范围内的 BAC 很少引起严重的中枢神经系统抑制或生命体征异常。这项研究质疑使用 400-500 mg/dl 作为所有患者类型的酒精致死范围的有效性。
We report a five month retrospective analysis of 204 consecutive patients seen in an adult medical emergency department with blood alcohol concentrations (BAC) in excess of 400 mg/dl. The average BAC was 467 mg/dl with a range of 400-719 mg/dl. In 153 patients (75%) the BAC was 400-500 mg/dl, in 47 patients (23%) the BAC was 500-600 mg/dl and in 4 patients (2%) the BAC was greater than 600 mg/dl. Eighty-eight percent of the patients were oriented to person, place, and time upon questioning, 12% were disoriented or unresponsive to noxious stimuli. None of the four patients whose BAC was greater than 600 mg/dl were initially alert and oriented and only eight of the unresponsive patients had a BAC below 500 mg/dl (p < .001). Sixteen patients (8%) were admitted. Three of the admissions were for continued unresponsiveness presumed due to ethanol, the other thirteen were for coexistent medical conditions. There were no significant associations between BAC and vital sign abnormalities. In this series, a BAC in the range of 400-500 mg/dl rarely caused profound CNS depression or vital sign abnormalities. This study questions the validity of utilizing 400-500 mg/dl as the lethal range of alcohol for all patient types.