Unusual trend in the prevalence of trisomy 13 in mothers aged 35 and older: A population based study of national congenital anomaly data.
Unusual trend in the prevalence of trisomy 13 in mothers aged 35 and older: A population based study of national congenital anomaly data.
复制标题
35 岁及以上母亲 13 三体患病率的异常趋势：基于国家先天异常数据的人口研究。
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
M. Morgan
中科院分区：
文献类型：
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作者：
D. Nair;D. Tucker;Rhian Hughes;Judith Greenacre;M. Morgan
背景
13号三体是与生存力相容的三种常染色体三体之一。它与结构异常、学习障碍和生存不良有关。高龄产妇是最常见的风险因素。这是一项基于人群的登记研究，旨在调查13三体的时间趋势。
方法
威尔士先天性异常登记处使用1998-2012年的数据对染色体三体进行了审查。包括所有妊娠结局。绘制了13、18和21三体所有病例以及母亲年龄低于35岁和35岁及以上病例的患病率和趋势。在研究的早期和后期，对导致高龄母亲这一趋势的可能风险因素进行了比较。
结果
在15年的时间里，有124例13三体，其中55名母亲年龄在35岁及以上。总体流行率为每10 000名新生儿中2.5人。35岁及以上母亲的13三体患病率呈显著下降趋势（χ（2）趋势= 4.98，p=0.026）。年轻母亲的死亡率较低，并保持稳定。大龄母亲中18三体和21三体的患病率保持稳定。
结论
本研究中检查的风险因素无法解释高龄母亲13三体综合征意外下降的趋势。近年来，没有其他关于高龄母亲13三体患病率趋势的报告。还需要对未来和其他人群的趋势进行监测。
BACKGROUND
Trisomy 13 is one of the three autosomal trisomies compatible with viability. It is associated with structural anomalies, learning disability and poor survival. Advanced maternal age is the most frequently suggested risk factor. This is a population based register study to investigate the temporal trends of trisomy 13.
METHODS
Chromosomal trisomies were reviewed by the Welsh Congenital Anomaly Register using data from 1998-2012. All pregnancy outcomes were included. Prevalence rates and trends for all cases and for cases with mothers aged below 35 years and those aged 35 years and older were plotted for trisomy 13, 18 and 21. Possible risk factors contributing to the trend in older mothers were compared in the early and late period of the study.
RESULTS
There were 124 cases of trisomy 13 over the 15 year period with 55 mothers aged 35 years and older. Overall prevalence was 2.5 per 10,000 total births. A significant declining trend in the prevalence of trisomy 13 in mothers aged 35 and older (χ(2) trend = 4.98, p=0.026) was noted. Rates for younger mothers were lower and remained stable. Prevalence of trisomy 18 and 21 in older mothers remained stable.
CONCLUSION
The unexpected declining trend in trisomy 13 in older mothers could not be explained by the risk factors examined in this study. There have been no other reports of trends in the prevalence of trisomy 13 in older mothers in recent years. There is further need for surveillance of trends in future and in other populations.