Sleep, Melatonin, and the Menopausal Transition: What Are the Links?
Sleep, Melatonin, and the Menopausal Transition: What Are the Links?
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睡眠、褪黑激素和更年期过渡：有何联系？
DOI：
10.5935/1984-0063.20170003
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发表时间：
2017-01
期刊：
影响因子：
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通讯作者：
Brzezinski A
中科院分区：
文献类型：
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作者：
Jehan S;Jean-Louis G;Zizi F;Auguste E;Pandi-Perumal SR;Gupta R;Attarian H;McFarlane SI;Hardeland R;Brzezinski A
松果体激素褪黑激素在调节昼夜睡眠/觉醒周期、情绪以及可能的免疫功能、致癌和生殖方面起着重要作用。人体松果体释放褪黑激素的昼夜节律与习惯性睡眠时间紧密同步。围绝经期和绝经后妇女经常抱怨难以启动和/或维持睡眠，夜间和清晨醒来频繁。在这篇综述中，我们讨论了褪黑激素功能的病理生理学，因为它涉及到更年期妇女的睡眠障碍，突出了潜在的使用外源性褪黑激素在绝经过渡期及以后。
The pineal hormone Melatonin plays an important role in the regulation of the circadian sleep/wake cycle, mood, and perhaps immune functions, carcinogensis and reproduction. The human circadian rhythm of melatonin release from the pineal gland is tightly synchronized with the habitual hours of sleep. Peri- and postmenopausal women often complain of difficulties initiating and/or maintaining sleep, with frequent nocturnal and early morning awakenings. In this review we discuss the pathophysiology of melatonin function as it relates to sleep disorders in menopausal women, highlighting the potential use of exogenous melatonin during the menopausal transition and beyond.