The regulation of pulmonary vascular tone.
The regulation of pulmonary vascular tone.
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DOI：
10.1046/j.1365-2125.1996.37117.x
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发表时间：
2003-10
影响因子：
3.4
通讯作者：
M. Wilkins;L. Zhao;R. Al-Tubuly
中科院分区：
文献类型：
--
作者：
M. Wilkins;L. Zhao;R. Al-Tubuly
1. 在药理学上操纵肺血管张力而不影响全身血管的能力是一个理想的目标。阐明缺氧诱导的肺血管收缩（HPV）的生化机制可能允许优先靶向肺循环。2. 在这里，我们回顾了我们的局部合成候选血管活性因子在HPV中的作用的研究。此外，我们提供的数据显示，与Wistar-Kyoto （WKY）大鼠品系相比，Fischer 344大鼠对肺循环缺氧的降压反应减弱。3. 我们建议使用HPV表型和一组高信息量的微卫星标记进行系统的全基因组搜索，将阐明这两种大鼠株中HPV易感性差异的遗传位点，并为确定HPV反应的因素提供有价值的新见解。
1. The ability to manipulate pharmacologically pulmonary vascular tone independent of effects on systemic blood vessels is a desirable objective. Elucidation of the biochemical mechanisms underlying hypoxia-induced pulmonary vasoconstriction (HPV) may permit preferential targeting of the pulmonary circulation. 2. Here we review our studies of the role of locally synthesized candidate vasoactive factors in HPV. In addition, we present data demonstrating an attenuated pressor response to hypoxia in the pulmonary circulation of Fischer 344 rats compared with the Wistar-Kyoto (WKY) rat strain. 3. We propose that a systematic genome-wide search using the HPV phenotype and a panel of highly informative microsatellite markers will elucidate the genetic loci underlying the difference in susceptibility to HPV in these two rat strains and provide a valuable and novel insight into the factors that determine the HPV response.