Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study:: does cysteine link amino acid and lipid metabolism?
Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study:: does cysteine link amino acid and lipid metabolism?
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DOI：
10.1093/ajcn/88.3.738
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发表时间：
2008-09-01
影响因子：
7.1
通讯作者：
Refsum, Helga
中科院分区：
文献类型：
--
作者：
Elshorbagy, Amany K.;Nurk, Eha;Refsum, Helga
背景：半胱硫氨酸β合成酶缺陷型同型半胱氨酸尿症的瘦肉型和血浆总半胱氨酸(TCys)与体重指数(BMI)呈正相关，提示总同型半胱氨酸(THcy)和tCys与体成分有关。目的：我们旨在研究普通人群中tCys和tHcy与身体成分的关系。设计：使用7038名荷尔蒙和同型半胱氨酸研究参与者的数据，我们将tCys和tHcy的回归模型和剂量-反应曲线与BMI进行拟合。在5179名参与者中，我们调查了tCys和tHcy与脂肪质量和瘦质量的关系，并检查了这些氨基硫醇的变化是否可以预测6年后的身体组成。结果：TCys与体重指数(Partial r=0.28，P<；0.001)、脂肪量(Partial r=0.25，P<；0.001)呈正相关，与饮食、运动和血脂无关。TCys最高五分位数的女性的脂肪质量比最低五分位数的女性多9公斤(95%可信区间：8，10公斤；P<；0.001)。男性的相应数值为6公斤(95%可信区间：5，7公斤；男女P<；0.001；P<；0.001，五分位数的方差分析)。TCys在6岁以上的升高与随访时较大的脂肪质量有关(P<；0.001)，但对瘦质量没有影响。THcy与瘦体重无关，只有在校正了tCys后，它才与BMI和脂肪质量显著负相关。THcy与瘦体重的相关性不显著。结论：TCys浓度与BMI呈显著正相关，这种关系是通过脂肪质量来实现的。半胱氨酸与脂质代谢之间的联系值得进一步研究。
Background: The lean phenotype of cystathionine beta-synthase-deficient homocystinuria and the positive association of plasma total cysteine (tCys) with body mass index (BMI) suggest that total homocysteine (tHcy) and tCys are associated with body composition. Objectives: We aimed to study associations of tCys and tHcy with body composition in the general population. Design: Using data from 7038 Hordaland Homocysteine Study participants, we fitted regression models and dose-response curves of tCys and tHcy with BMI. In 5179 participants, we investigated associations of tCys and tHcy with fat mass and lean mass and examined whether changes in these aminothiols predicted body composition 6 y later. Results: tCys showed positive associations with BMI (partial r = 0.28, P < 0.001), and fat mass (partial r = 0.25, P < 0.001), independent of diet, exercise, and plasma lipids. Women in the highest tCys quintile had fat mass 9 kg (95% CI: 8, 10 kg; P < 0.001) greater than that of women in the lowest quintile. The corresponding values for men were 6 kg (95% CI: 5, 7 kg; P < 0.001; P < 0.001 in both sexes, ANOVA across quintiles). The rise in tCys over 6 y was associated with greater fat mass at follow-up (P < 0.001), but there was no effect on lean mass. tHcy was not associated with lean mass, and it became significantly inversely associated with BMI and fat mass only after adjustment for tCys. The association between tHcy and lean mass was not significant. Conclusions: tCys concentrations show a strong positive association with BMI, mediated through fat mass. The link between cysteine and lipid metabolism deserves further investigation.