Salvinorin A reduces neuropathic nociception in the insular cortex of the rat
Salvinorin A reduces neuropathic nociception in the insular cortex of the rat
复制标题
鼠尾草素A降低大鼠岛叶皮层中的神经性伤害感受
DOI：
10.1002/ejp.1120
复制
发表时间：
2018-02-01
影响因子：
3.6
通讯作者：
Pellicer, F.
中科院分区：
文献类型：
--
作者：
Coffeen, U.;Canseco-Alba, A.;Pellicer, F.
背景神经病理性疼痛是公共卫生领域最重要的挑战之一。寻找新的治疗方法对于充分缓解而无不良反应很重要。从这个意义上说，鼠尾草素A（salvinorin B，SA），药用植物鼠尾草（Salvia divinorum）的主要二萜是一种重要的抗伤害性化合物，其作为κ阿片受体（KOR）和大麻素CB 1受体的有效激动剂。KOR和CB1拮抗剂直接在岛叶皮层（IC）在雄性wistarrats.ResultsWe发现了一个强大的抗伤害性作用与管理SA。此外，这种效果被封锁的一个KOR拮抗剂的管理，以及管理的CB1 antagonist.ConclusionSalvinorin A有一个强大的抗伤害性作用时，集中管理在IC通过与KOR和CB1 receptors. Significance的相互作用，我们显示证据的有效性管理salvinorin A在IC在啮齿动物模型的神经性疼痛。这些结果支持使用新型化合物如SA作为神经性疼痛缓解的治疗替代方案。
BackgroundNeuropathic pain is one of the most important challenges in public health. The search for novel treatments is important for an adequate relief without adverse effects. In this sense salvinorin A (SA), the main diterpene of the medicinal plant Salvia divinorum is an important antinociceptive compound, which acts as a potent agonist of kappa opioid receptor (KOR) and cannabinoid CB1 receptors.MethodsWe evaluated nociceptive responses in a neuropathic pain model induced by the sciatic nerve ligature (SNL) in the right hind paw, after the microinjection of SA, Salvinorin B (SB), KOR and CB1 antagonists directly in the insular cortex (IC) in male wistar rats.ResultsWe found a potent antinociceptive effect with the administration of SA. Moreover, this effect was blocked by the administration of a KOR antagonist as well as the administration of a CB1 antagonist.ConclusionSalvinorin A has a potent antinociceptive effect when is administered centrally in the IC by the interaction with KOR and CB1 receptors.SignificanceWe show evidence on the effectiveness of the administration of salvinorin A in the IC in a rodent model of neuropathic pain. These results support the use of novel compounds like SA as a therapeutic alternative for neuropathic pain relief.