Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia.
Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia.
复制标题
DOI：
10.1080/23723556.2016.1157667
复制
发表时间：
2016-07
影响因子：
2.1
通讯作者：
Brown JR
中科院分区：
文献类型：
--
作者：
Kasar S;Brown JR
测序研究有助于了解慢性淋巴细胞白血病（CLL）的遗传基础。我们最近的全基因组测序研究集中在较低的细胞遗传学风险CLL表明，CLL突变可以归因于3个关键的突变过程-2种类型的激活诱导-胞苷脱氨酶（AID）签名和老化签名-在整个CLL进化的不同时间运行。
Sequencing studies have been instrumental in understanding the genetic basis of chronic lymphocytic leukemia (CLL). Our recent whole-genome sequencing study focusing on lower cytogenetic risk CLL demonstrated that CLL mutations can be attributed to 3 key mutational processes—2 types of activation induced-cytidine deaminase (AID) signatures and an aging signature—that operate at different times throughout CLL evolution.