Age- and gender-dependent changes in three-dimensional microstructure of cortical and trabecular bone at the human femoral neck
Age- and gender-dependent changes in three-dimensional microstructure of cortical and trabecular bone at the human femoral neck
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DOI：
10.1007/s00198-009-0993-z
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发表时间：
2010-04-01
影响因子：
4
通讯作者：
Bunai, Y.
中科院分区：
文献类型：
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作者：
Chen, H.;Zhou, X.;Bunai, Y.
我们研究了人类股骨颈皮质和骨小梁显微结构的年龄和性别相关变化。我们发现皮质孔隙度的年龄相关性变化比骨小梁参数的变化更明显。我们的数据可能有助于更深入地了解骨质疏松性股骨颈骨折的潜在机制。皮质骨和松质骨的微观结构的变化有助于降低骨强度。股骨颈皮质和骨小梁显微结构的年龄和性别相关变化尚不清楚。本研究的目的是确定三维（3D）的微观结构变化的皮质骨和松质骨同时在人类股骨颈与年龄和性别，使用微型计算机断层扫描（micro-CT）。我们假设女性和男性的皮质骨和松质骨的年龄相关变化存在差异，我们使用了来自日本人群的28名女性和男性（57-98岁）的56个股骨颈。受试者的年龄和性别分布均匀。妇女和男子均分为三个年龄组：中年（57-68岁）、老年（72-82岁）和老年（87-98岁）组。我们使用微型CT和3D骨分析软件检查了股骨颈下段的皮质骨标本和股骨颈中部的松质骨标本。皮质厚度（Ct.Th）减少了10- 15%，皮质孔隙率（Ca.V/TV）几乎增加了一倍，管直径（Ca.Dm）增加了65-77%中年和老年组女性和男性。女性和男性的骨小梁体积分数（BV/TV）降低约20%;骨小梁厚度（Tb.Th）、骨小梁数量（Tb.N）和连接密度（Conn.D）降低;骨小梁分离（Tb.Sp）和结构模型指数（SMI）随年龄增加。3个年龄组中，男性Ct.Th、BV/TV均高于女性，Ca.V/TV、Ca.Dm低于女性。结果表明，女性和男性股骨颈的Ct.Th和BV/TV均随年龄的增长而降低，Ca.V/TV和Ca.Dm均随年龄的增长而升高。最明显的增龄变化是Ca.V/TV的增加。BV/TV随年龄的下降比Ct. Th更明显。这是第一项同时提供日本样本皮质和小梁显微结构数据的研究。这些数据可能有助于我们更深入地了解股骨颈骨折的潜在机制。
We investigated age- and gender-related variation of both cortical and trabecular microstructure in human femoral neck. We found that age-related change of cortical porosity is more noticeable than that of trabecular parameter. Our data may help to gain more insight into the potential mechanism of osteoporotic femoral neck fractures.Variations in the microstructure of cortical and trabecular bone contribute to decreased bone strength. Age- and gender-related changes in cortical and trabecular microstructure of femoral neck is unclear. The aim of this study was to identify three-dimensional (3D) microstructural changes of both cortical and trabecular bone simultaneously in human femoral neck with age and gender, using micro-computed tomography (micro-CT). We hypothesized that there would be differences in age-related changes of cortical and trabecular bone for both women and men.We used 56 femoral necks of 28 women and men (57-98 years of age) from a Japanese population. The subjects were chosen to give an even age and gender distribution. Both women and men were divided into three age groups: middle (57-68 years), old (72-82 years), and elderly (87-98 years) groups. We examined cortical bone specimen from the inferior sector of femoral neck and trabecular bone specimen from the middle of femoral neck using micro-CT and 3D bone analysis software.Cortical thickness (Ct.Th) decreased by 10-15%, cortical porosity (Ca.V/TV) almost doubled, and canal diameter (Ca.Dm) increased by 65-77% between the middle-aged and elderly groups for both women and men. The trabecular bone volume fraction (BV/TV) decreased by around 20%; trabecular thickness (Tb.Th), trabecular number (Tb.N), and connectivity density (Conn.D) decreased; and trabecular separation (Tb.Sp) and structure model index (SMI) increased with age for both women and men. As compared with women, men had higher Ct.Th and BV/TV and lower Ca.V/TV and Ca.Dm among three age groups. There was a significant inverse correlation between Ca.V.TV and BV/TV for both women and men.Our findings indicate that Ct.Th and BV/TV decreased, and Ca.V/TV and Ca.Dm increased in femoral neck with age for both women and men. The most obvious age-related change is the increase of Ca.V/TV. The decrease of BV/TV with age is more noticeable than that of Ct.Th. This is the first study that has provided both cortical and trabecular microstructural data simultaneously in a Japanese sample. These data may help us to gain more insight into the potential mechanism of osteoporotic femoral neck fractures.