STRUCTURAL CHANGES IN THE CNS OF PATIENTS WITH HEMIFACIAL SPASM
STRUCTURAL CHANGES IN THE CNS OF PATIENTS WITH HEMIFACIAL SPASM
复制标题
面肌痉挛患者中枢神经系统的结构变化
DOI：
10.1016/j.neuroscience.2014.12.070
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发表时间：
2015-03-19
期刊：
影响因子：
3.3
通讯作者：
Zhang, M.
中科院分区：
文献类型：
--
作者：
Bao, F.;Wang, Y.;Zhang, M.
面肌痉挛是一种严重影响患者身心生活质量的周围神经疾病。HFS是否在这些特定的应激源（包括中枢神经系统的心理和生理条件）下发生结构变化，在很大程度上仍不清楚。在本研究中，基于体素的形态测量（VBM）被用来评估灰质（GM）的变化，通过使用T1加权成像在25例HFS患者和25例人口统计学相似的健康志愿者。使用Cohen评估量表评估痉挛的严重程度。采用汉密尔顿焦虑量表（HAMA）和汉密尔顿抑郁量表（HAMD）评定受试者的情感状况。应用3D-FIESTA和3D-TOF序列评价每例受试者的神经血管压迫（NVC）评分。结果发现，HFS患者的NVC评分高于健康志愿者，痉挛严重程度评分与NVC评分呈正相关（r = 0.736，p < 0.001）。HFS患者HAMA和HAMD评分高于健康志愿者。对于GM比较，与健康志愿者相比，HFS患者的丘脑、壳核、苍白球、背外侧前额叶皮质、杏仁核和海马旁回减少。此外，以HAMA和HAMD评分作为协变量，杏仁核GM体积变化未表现出任何显著的组间差异。我们的研究结果表明，HFS可能导致GM的体积异常的CNS。提示杏仁核GM体积的变化可能与情绪因素密切相关。(C)2015年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Hemifacial spasm (HFS) is a peripheral nerve disorder which impacts the living quality of patients both psychologically and physically. Whether HFS has structural changes under these specific stressors including psychological and physiological conditions in the CNS remains largely unknown. In the current study, voxel-based morphometry (VBM) was used to evaluate changes in gray matter (GM) by using T1-weighted imaging in 25 HFS patients and 25 demographically similar healthy volunteers. The severity of the spasm was assessed using a Cohen evaluation scale. Hamilton anxiety (HAMA) and Hamilton depression (HAMD) rating scales were used to evaluate the affective conditions of subjects. 3D-FIESTA and 3D-TOF sequences were applied to evaluate the neurovascular compression (NVC) rating in each subject. In our results, we found that HFS patients had higher NVC rating scores than those of healthy volunteers, and the spasm severity rating was positively correlated with the NVC rating (r = 0.736, p < 0.001). HFS patients had higher scores on the HAMA and HAMD compared with healthy volunteers. For the GM comparison, reductions were found in the thalamus, putamen, pallidum, dorsolateral prefrontal cortex, amygdala and parahippocampal gyrus in patients with HFS compared with healthy volunteers. Additionally, the GM volume changes in the amygdala did not exhibit any significant between-group differences with HAMA and HAMD scores as covariates. Our results suggested that HFS probably led to GM volume abnormalities of the CNS. We indicated that the GM volume changes of the amygdala may be highly related to emotional factors. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.