RELATIONSHIP BETWEEN CHANGED ALVEOLAR-CAPILLARY PERMEABILITY AND ANGIOTENSIN CONVERTING ENZYME-ACTIVITY IN SERUM IN SARCOIDOSIS
RELATIONSHIP BETWEEN CHANGED ALVEOLAR-CAPILLARY PERMEABILITY AND ANGIOTENSIN CONVERTING ENZYME-ACTIVITY IN SERUM IN SARCOIDOSIS
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DOI：
10.1136/thx.41.8.629
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发表时间：
1986-08-01
期刊：
影响因子：
10
通讯作者：
BLASCHKE, E
中科院分区：
文献类型：
--
作者：
EKLUND, A;BLASCHKE, E
为探讨肺泡毛细血管通透性改变对45例结节病患者和21例健康人血清血管紧张素转换酶(ACE)活性的影响。结节病患者支气管肺泡灌洗液中白蛋白浓度升高(L白蛋白)，L白蛋白/血清白蛋白比值增加(S白蛋白)，提示肺泡毛细血管膜通透性增加。对照组灌洗液中ACE活性与肺泡巨噬细胞数呈正相关，提示可能来源于肺泡巨噬细胞。在活动期结节病患者中，Lace含量较高，而在非活动期疾病患者中，则与对照组相似。结节病的SACE显著增加。在L白蛋白升高的患者中，90%的患者SACE升高。SACE活性与L白蛋白浓度和花边活性呈显著正相关。膜通透性增加的征象与SACE以及LACE与SACE之间的关系表明，结节病中过量的SACE可能至少部分起源于肺泡腔。
The effect of altered alveolar-capillary permeability on angiotensin converting enzyme (ACE) activity in serum (SACE) was studied in 45 patients with sarcoidosis and 21 healthy controls. In sarcoidosis increased albumin concentrations in the bronchoalveolar lavage fluid (L albumin) and increased ratios of L albumin to albumin in serum (S albumin) indicated an increased permeability of the alveolar-capillary membrane. ACE activity in the lavage fluid (LACE) was correlated with the number of alveolar macrophages in controls, indicating that it may come from these cells. LACE was high in active sarcoidosis while in inactive disease it was similar to that in controls. SACE in sarcoidosis was significantly increased. Ninety per cent of patients with increased L albumin had increased SACE. SACE activity was significantly correlated with concentrations of L albumin and with LACE activity. The relationships between signs of increased membrane permeability and SACE and between LACE and SACE suggest that excess SACE in sarcoidosis may, at least partly, originate in the alveolar space.