DEVELOPMENTAL FEATURES OF THE NEONATAL BRAIN - MR IMAGING .1. GRAY-WHITE MATTER DIFFERENTIATION AND MYELINATION
DEVELOPMENTAL FEATURES OF THE NEONATAL BRAIN - MR IMAGING .1. GRAY-WHITE MATTER DIFFERENTIATION AND MYELINATION
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DOI：
10.1148/radiology.162.1.3786767
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发表时间：
1987-01-01
期刊：
影响因子：
19.7
通讯作者：
AMPARO, EG
中科院分区：
文献类型：
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作者：
MCARDLE, CB;RICHARDSON, CJ;AMPARO, EG
为了确定新生儿大脑的正常外观，在前瞻性研究中，51例怀孕29-42周的新生儿接受了0.6-T磁体的磁共振成像。T1加权图像用于灰白质分化的出现和髓鞘形成程度的分期。结果表明，在妊娠29~42周，灰白质分化和髓鞘形成的变化遵循有序和可预测的方式。白质强度的变化似乎与大脑水分含量的进行性下降有关。髓鞘形成在29周时从脑干进入头部，42周时到达半卵圆中心。9名围产期病程复杂的婴儿出现髓鞘延迟，定义为放射状冠髓鞘消失37周。对这些发育特征的认识应有助于最大限度地减少对新生儿大脑正常变化的误解，并通过磁共振成像和计算机断层扫描及早发现病理情况。
To establish the normal appearance of the neonatal brain, 51 neonates, 29-42 weeks postconception, underwent magnetic resonance (MR) imaging with 0.6-T magnet in a prospective study. T1-weighted images were used to devise stages for the appearance of gray-white matter differentiation and extent of myelination. The results show that from 29 to 42 weeks postconception changes in gray-white matter differentiation and myelination follow the stages in an orderly and predictable fashion. Changes in white matter intensity appear related to progressive decrease in brain water content. Myelination progresses cephalaed from the brain stem at 29 weeks to reach the centrum semiovale by 42 weeks. Delayed myelination, defined as the absence of myelin in the corona radiata by 37 weeks, was seen in nine infants with complicated perinatal courses. Awareness of these developmental features should help to minimize misinterpretation of normal changes in the neonatal brain and lead to earlier detection of pathologic conditions, both with MR imaging and computed tomography.