Calcium involvement in free radical effects
Calcium involvement in free radical effects
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钙参与自由基效应
DOI：
--
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发表时间：
1992
影响因子：
4.2
通讯作者：
R. Bracci
中科院分区：
文献类型：
--
作者：
R. Bracci
自由基是分子的碎片，或带有一个或多个未成对电子的原子。它们参与许多生物反应，在过去的十年中，人们认为它们在各种疾病的发展中起着重要作用。许多分子可以归类为自由基。从参与疾病过程的角度来看，最重要的报告见表[1，2]。最常见的反应见表2 [24]。对抗自由基的氧化作用的试剂被称为抗氧化剂，并且也非常多[4，5]。其中一些报告见表3。自由基的产生不仅仅是一种病理事件，它还广泛参与许多生理功能的调节。这个问题被比作一个平衡，当它倾向于自由基时意味着疾病，当它倾向于抗氧化剂时，健康[4]。虽然这是相当简单的，因为无数的事件可能存在于两个尺度上，但本书解释了基本概念，即未充分解毒的自由基可能与各种分子反应，通过使细胞外空间和细胞结构中的蛋白质变性和脂质过氧化而产生组织损伤。五种自由基产生模式值得一提：高氧、对外源性物质的反应[6，7]、花生四烯酸代谢期间的反应[8，9]、吞噬作用期间的爆发活性[10，11]和缺血再灌注期间的反应[12，13-16]。这些机制中的每一种都涉及重要的病理事件，如氧化溶血、脑和心肌损伤以及炎性损伤。虽然自由基释放已被证明在广泛的疾病，他们的真实的重要性在组织损伤的初始阶段仍然不清楚。因此，值得一提的是它们对细胞代谢的一些影响，例如涉及钙的影响。
Free radicals are fragments of molecules, or atoms with one or more unpaired electrons. They are involved in many biological reactions and in the last decade it has been suggested that they play an important role in the development of various diseases. Many molecules can be classified as free radicals. The most important from the point of view of involvement in disease processes are reported in Table [1, 2]. The most common reactions are in Table 2 [24]. Agents opposing the oxidative effects of free radicals are known as antioxidants and are also very numerous [4, 5]. Some of them are reported in Table 3. The development of free radicals is far from being only a pathological event but participates widely in the modulation of many physiological functions. The problem has been likened to a balance which when it tips towards free radicals means disease and when it tips towards antioxidants, health [4]. Although this is rather simplistic as a myriad of events may lie on both scales, the simile explains the basic concept that inadequately detoxified free radicals may react with various molecules producing tissue damage by denaturing proteins and peroxidizing lipids in the extracellular space and in cell structures. Five modes of free radical yielding deserve to be mentioned: hyperoxia, reactions to xenobiotics [6, 7], reactions during arachidonic acid metabolism [8, 9], burst activity during phagocytosis [10, 11], and reactions during ischemiareperfusion [12, 13-16]. Each of these mechanisms is involved in important pathological events such as oxidative hemolysis, brain and myocardial injury, and inflammatory damage. Although free radical release has been demonstrated in a wide range of diseases, their real importance in the initial stage of tissue damage is still unclear. Hence, it is worthwhile mentioning some of their effects on cell metabolism, such as that involving calcium.
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人红细胞、胎盘和肺的阴离子谷胱甘肽 S-转移酶：结构差异的证据。
DOI：
10.1159/000469022
发表时间：
1989
期刊：
Enzyme
影响因子：
--
作者：
Ahmad,H;Medh,RD;Singh,SV;Caccuri,AM;Ansari,GA;Awasthi,YC
通讯作者：
Awasthi,YC
影响因子：
20.3
作者：
B. Babior
通讯作者：
B. Babior
药物引起的红细胞氧化变性。
影响因子：
3.6
作者：
Stern,A
通讯作者：
Stern,A
影响因子：
15.9
作者：
SNYDER, LM;FORTIER, NL;MOHANDAS, N
通讯作者：
MOHANDAS, N
氧化应激：一种激进的观点。
影响因子：
3.6
作者：
Saltman,P
通讯作者：
Saltman,P