Endurance training increases the number of endothelial progenitor cells in patients with cardiovascular risk and coronary artery disease
Endurance training increases the number of endothelial progenitor cells in patients with cardiovascular risk and coronary artery disease
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DOI：
10.1016/j.atherosclerosis.2005.01.006
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发表时间：
2005-08-01
期刊：
影响因子：
5.3
通讯作者：
Kopp, CW
中科院分区：
文献类型：
--
作者：
Steiner, S;Niessner, A;Kopp, CW
目的：由于有规律的体育锻炼可以改善内皮功能障碍并促进心血管健康，我们通过测量循环内皮祖细胞（EPC）数量和EPC动员生长因子水平来研究锻炼对血管生成的影响，并通过流动介导的扩张（FMD）来检测冠状动脉疾病（CAD）和心血管危险因素（CVRF）患者的血管功能。此外，降解产物的NO途径（NO，）determined.Methods和结果：20例记录CAD和/或CVRF参加了为期12周的监督运行训练。循环EPCs -由表面标志物CD 34，KDR和CD 133定义-在基线和运动训练后通过流式细胞术测量。我们发现循环EPCs显著增加（增加2.9 +/- 0.4倍; P <0.0001），这与FMD的变化（r = 0.81 P <0.001）和NOx合成的增加（r = 0.83，P <0.001）呈正相关。血浆VEGF和促红细胞生成素在运动后没有变化。然而.我们观察到EPCs和促红细胞生成素的数量在基线（r = 0.70，P <0.01）和训练后（r = 0.73，P <0.01）之间呈正相关。结论：有规律的运动训练增加了CVRF和CAD患者循环EPCs的数量，并与血管功能和NO合成的改善有关。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Objective : As regular physical exercise improves endothelial dysfunction and promotes cardiovascular health, we investigated the effect of training on angiogenesis by measuring the number of circulating endothelial progenitor cells (EPC), the level of EPC-mobilizing growth factors and tested vascular function by flow-mediated dilation (FMD) in patients with coronary artery disease (CAD) and cardiovascular risk factors (CVRF). In addition, degradation products of the NO pathway (NO,) were determined.Methods and results : Twenty patients with documented CAD and/or CVRF joined a 12-week supervised running training. Circulating EPCs - defined by the surface markers CD34, KDR and CD133 - were measured at baseline and after exercise training by flow cytometry. We found a significant increase in circulating EPCs (2.9 +/- 0.4-fold increase; P < .0001), which was positively correlated with both, the change of FMD (r = .81 P < .001) and the increase of NOx synthesis (r = .83, P < .001). Plasma VEGF and erythropoietin did not change in response to exercise. However. we observed a positive correlation between the number of EPCs and erythropoietin at baseline (r = .70, P < .01) and after training (r = .73, P < .01).Conclusions : Regular exercise training augments the number of circulating EPCs in patients with CVRF and CAD and is associated with improved vascular function and NO synthesis. (c) 2005 Elsevier Ireland Ltd. All rights reserved.