Treatment outcome of advance staged oral cavity cancer: concurrent chemoradiotherapy compared with primary surgery
Treatment outcome of advance staged oral cavity cancer: concurrent chemoradiotherapy compared with primary surgery
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DOI：
10.1007/s00405-017-4540-9
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发表时间：
2017-06-01
影响因子：
2.6
通讯作者：
Leelasawatsuk, Peesit
中科院分区：
文献类型：
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作者：
Tangthongkum, Manupol;Kirtsreesakul, Virat;Leelasawatsuk, Peesit
同步放化疗（CCRT）已被报道是有效的，并已成为一个可接受的治疗晚期口腔癌。然而，到目前为止，没有足够的数据得出结论，CCRT提供了良好的生存结局。本研究的目的是比较可切除的晚期口腔鳞状细胞癌患者接受CCRT或手术联合辅助放疗（RT）/放化疗（CRT）治疗的生存率和并发症。在7年期间（2009-2015年），确定了通过CCRT或辅助RT手术治疗的III期或IVa期口腔癌患者。分析比较两组患者的生存率和治疗并发症。61例患者接受了CCRT，128例患者接受了手术切除并接受了术后RT。两个治疗组之间的生存结局无统计学显著差异。5-CCRT组和手术加辅助RT/CRT组的总生存率（OS）分别为33%和24%（P = 0.191），疾病特异性生存率（DSS）分别为27%和25%（P = 0.857）。两组的长期并发症相当。CCRT治疗晚期口腔鳞状细胞癌的生存结局和并发症与手术辅助RT/CRT相当。
Concurrent chemoradiotherapy (CCRT) has been reported as effective and has become an acceptable treatment in advanced oral cancer. However, to date there is insufficient data to conclude that CCRT provides a good survival outcome. The purpose of this study was to compare survival rates and complications in patients with resectable advanced oral cavity squamous cell carcinoma treated with either CCRT or surgery with adjuvant radiotherapy (RT)/chemoradiotherapy (CRT). Stage III or IVa oral cavity carcinoma patients treated with curative intent by either CCRT or surgery with adjuvant RT were identified over a 7-year period (2009-2015). Survival rates and treatment complications were analyzed and compared between the two groups. 61 patients underwent CCRT and 128 patients underwent surgical excision and received postoperative RT. There was no statistically significant difference in survival outcome between the two treatment groups. 5-year overall survival rates (OS) were 33 versus 24% (P = 0.191) and the disease-specific survival rates (DSS) were 27 versus 25% (P = 0.857) when comparing the CCRT group and surgery with adjuvant RT/CRT group, respectively. Long-term complications were comparable between the two groups. CCRT has comparable survival outcome and complications for the treatment of advanced oral cavity squamous cell carcinoma, compared to surgery with adjuvant RT/CRT.