Pyrrole alkaloids from the fruits of Morus alba
Pyrrole alkaloids from the fruits of Morus alba
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DOI：
10.1016/j.bmcl.2014.10.073
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发表时间：
2014-12-15
影响因子：
2.7
通讯作者：
Lee, Mi Kyeong
中科院分区：
文献类型：
--
作者：
Kim, Seon Beom;Chang, Bo Yoon;Lee, Mi Kyeong
从桑果实中分离得到17个吡咯类生物碱，其中5个为新化合物。本文报道了五个新的吡咯生物碱，命名为吗啉素B-F（4，5，7，16，17）。4-[甲酰基-5-（羟甲基）-1H-吡咯-1-基]丁酸酯（2）是通过化学反应合成的，但首次从自然界中分离得到。在分离的化合物中，化合物6和14显著抑制胰脂肪酶活性。(C)2014爱思唯尔有限公司版权所有。
Phytochemical investigation of the fruits of Morus alba afforded seventeen pyrrole alkaloids including five new compounds. The structures of five new pyrrole alkaloids, named morroles B-F (4, 5, 7, 16 and 17), were determined on the basis of spectroscopic interpretations. 4-[Formyl-5-(hydroxymethyl)-1Hpyrrol-1-yl]butanoate (2) was synthesized by chemical reaction but first isolated from nature. Among isolated compounds, compounds 6 and 14 significantly inhibited pancreatic lipase activity. (C) 2014 Elsevier Ltd. All rights reserved.