Asymptomatic Prenatal Zika Virus Infection and Congenital Zika Syndrome
Asymptomatic Prenatal Zika Virus Infection and Congenital Zika Syndrome
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DOI：
10.1093/ofid/ofy073
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发表时间：
2018-04-01
影响因子：
4.2
通讯作者：
Wilder-Smith, Annelies
中科院分区：
文献类型：
--
作者：
Paixao, Enny S.;Leong, Wei-Yee;Wilder-Smith, Annelies
为了调查无症状与有症状的产前寨卡病毒感染在多大程度上导致出生缺陷，我们确定了3项前瞻性和8项回顾性研究。在回顾性研究中，这一比例差异很大，最可能是由于招募和回忆偏倚。前瞻性研究显示，无症状与有症状的母体寨卡病毒感染的比例为1：1，导致不良胎儿结局。
To investigate to what extent asymptomatic vs symptomatic prenatal Zika virus infections contribute to birth defects, we identified 3 prospective and 8 retrospective studies. The ratio varied greatly in the retrospective studies, most likely due to recruitment and recall bias. The prospective studies revealed a ratio of 1: 1 for asymptomatic vs symptomatic maternal Zika infections resulting in adverse fetal outcomes.