Mechanochemistry:: targeted delivery of single molecules
Mechanochemistry:: targeted delivery of single molecules
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DOI：
10.1038/nnano.2006.92
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发表时间：
2006-11-01
影响因子：
38.3
通讯作者：
Zerbetto, Francesco
中科院分区：
文献类型：
--
作者：
Duwez, Anne-Sophie;Cuenot, Stephane;Zerbetto, Francesco
使用基于扫描探针显微镜的技术来操纵单个分子（1）并以精确控制的方式将它们递送到特定目标代表了重大的纳米技术挑战（2，3）。使用这种方法可以达到有机表面设计和制造的最终物理极限。在这里，我们展示了原子力显微镜（AFM），它已被广泛用于研究单个分子的拉伸（4-12），可以提供和固定单个分子，一次一个，在表面上。反应性聚合物分子，在一端连接到AFM针尖，与改性的硅衬底接触，它们通过化学反应连接到衬底上。当AFM针尖被拉离表面时，产生的机械力会导致最弱的键-针尖和聚合物之间的键-断裂。这个过程将聚合物分子转移到基底上，在那里它可以通过进一步的化学反应进行修饰。
The use of scanning probe microscopy-based techniques to manipulate single molecules(1) and deliver them in a precisely controlled manner to a specific target represents a significant nanotechnological challenge(2,3). The ultimate physical limit in the design and fabrication of organic surfaces can be reached using this approach. Here we show that the atomic force microscope (AFM), which has been used extensively to investigate the stretching of individual molecules(4-12), can deliver and immobilize single molecules, one at a time, on a surface. Reactive polymer molecules, attached at one end to an AFM tip, are brought into contact with a modified silicon substrate to which they become linked by a chemical reaction. When the AFM tip is pulled away from the surface, the resulting mechanical force causes the weakest bond - the one between the tip and polymer - to break. This process transfers the polymer molecule to the substrate where it can be modified by further chemical reactions.