Vitamin D supplementation reduces insulin resistance in Japanese adults: a secondary analysis of a double-blind, randomized, placebo-controlled trial
Vitamin D supplementation reduces insulin resistance in Japanese adults: a secondary analysis of a double-blind, randomized, placebo-controlled trial
复制标题
补充维生素 D 可降低日本成年人的胰岛素抵抗：双盲、随机、安慰剂对照试验的二次分析
DOI：
10.1016/j.nutres.2016.07.006
复制
发表时间：
2016-10-01
影响因子：
4.5
通讯作者：
Higuchi, Mitsuru
中科院分区：
文献类型：
--
作者：
Sun, Xiaomin;Cao, Zhen-Bo;Higuchi, Mitsuru
较高的循环25-羟基维生素D（25[OH]D）浓度与较低的胰岛素抵抗和2型糖尿病患病率有关。然而，随机对照试验尚未阐明维生素D补充剂对健康成人胰岛素抵抗的影响。本研究的目的是评估维生素D补充1年对胰岛素抵抗的影响;该研究是临床试验的次要分析。我们假设，维生素D补充1年后，25（OH）D浓度增加将显着改善胰岛素抵抗。96名健康成年人参加了这项研究，其中81人完成了研究。参与者每天随机接受420 IU维生素D3或安慰剂，以双盲方式持续1年。在基线和干预1年后评估空腹胰岛素、血糖和其他参数的水平。根据胰岛素和血糖水平计算胰岛素抵抗指数的稳态模型评估。内脏脂肪面积和体力活动也进行了调查。补充维生素D 1年后，血清25（OH）D和1，25-二羟维生素D浓度分别显著增加约29.5 nmol/L和7.0 pg/mL。补充维生素D后，空腹血糖水平和胰岛素抵抗指数的稳态模型评估值分别从88.3降至85.3 mg/dL（P <0.01）和1.17降至0.84（P <0.01），结果与体力活动和内脏脂肪堆积无关。总之，本研究表明，维生素D补充1年有效地改善了健康日本成年人的空腹血糖水平和胰岛素抵抗。(C)2016 Elsevier Inc. All rights reserved.
Higher circulating 25-hydroxyvitamin D (25[OH]D) concentration has been linked to a lower prevalence of insulin resistance and type 2 diabetes mellitus. However, randomized controlled trials have not clarified the effect of vitamin D supplementation on insulin resistance in healthy adults. The objective of this study was to assess the effect of vitamin D supplementation for 1 year on insulin resistance; the study was a secondary analysis of a clinical trial. We hypothesized that increased 25(OH)D concentration after vitamin D supplementation for 1 year would significantly improve insulin resistance. Ninety-six healthy adults participated in this study, of whom 81 completed the study. The participants randomly received daily either 420 IU vitamin D3 or placebo in a double-blind manner for 1 year. The levels of fasting insulin, glucose, and other parameters were assessed at baseline and after 1 year of intervention. Homeostasis model assessment of insulin resistance index was calculated from insulin and glucose levels. Visceral fat area and physical activity were also investigated. Serum 25(OH)D and 1,25-dihydroxyvitamin D concentrations were significantly increased by approximately 29.5 nmol/L and 7.0 pg/mL, respectively, after 1-year vitamin D supplementation. After vitamin D supplementation, fasting glucose levels and values of homeostasis model assessment of insulin resistance index significantly decreased from 88.3 to 85.3 mg/dL (P < .01) and 1.17 to 0.84 (P < .01), respectively, and the results were independent of physical activity and visceral fat accumulation. In conclusion, the present study showed that vitamin D supplementation for 1 year effectively improves fasting glucose level and insulin resistance in healthy Japanese adults. (C) 2016 Elsevier Inc. All rights reserved.