Exposure to pets and atopic dermatitis during the first two years of life. A cohort study
Exposure to pets and atopic dermatitis during the first two years of life. A cohort study
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在生命的头两年内接触宠物和特应性皮炎。
DOI：
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发表时间：
2002
影响因子：
4.4
通讯作者：
J. Heinrich
中科院分区：
文献类型：
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作者：
A. Zirngibl;K. Franke;U. Gehring;A. von Berg;D. Berdel;C. Bauer;D. Reinhardt;H. Wichmann;J. Heinrich
本研究的目的是评估儿童早期饲养宠物与持续出生队列中直至 2 岁的特应性皮炎发生之间的关联。我们在一项正在进行的队列研究的干预和观察部分分析了 4578 名儿童的数据。 1996 年 1 月至 1998 年 6 月期间，这些儿童在韦塞尔和慕尼黑这两个研究地区一出生就被招募。有关特应性疾病和宠物饲养的信息是在孩子一岁和两岁生日时通过问卷调查获得的。逻辑回归模型显示，在出生后第一年“养任何宠物”，特别是“养狗”，与出生后第一年和第二年患特应性皮炎呈负相关。调整几个可能的混杂变量后，保护作用仍然具有统计学显着性（第一年任何宠物 OR 0.71，95% CI [0.55;0.92]，第一年狗 OR 0.62，95% CI [0.39;0.98]，第二年任何宠物 OR 0.74，95% CI [0.57;0.97]，第二年狗 OR 0.63， 95% CI [0.40;0.98]）。拥有小型毛皮宠物（仓鼠、兔子和豚鼠）在第一年也显示出边缘保护作用。我们假设饲养宠物和未定义的环境因素之间存在关联，这些因素可能通过影响免疫系统的成熟，对生命早期特应性皮炎的发展起到保护作用。
The aim of this study was to assess the association between keeping pets in early childhood and the occurrence of atopic dermatitis in an ongoing birth cohort followed up to the age of 2 years. We analyzed data of 4578 children in the intervention and observation part of an ongoing cohort study. The children were recruited at birth in the two study regions Wesel and Munich between January 1996 and June 1998. Information on atopic diseases and pet ownership was obtained by questionnaire at the child's first and second birthday. The logistic regression model showed a negative association between ‘keeping any pet’ and in particular ‘keeping dogs’ in the 1st year of life and the development of atopic dermatitis in the 1st and the 2nd years of life. The protective effects remained statistically significant after adjusting for several possible confounding variables (1st yearany pet OR 0.71, 95% CI [0.55;0.92], 1st yeardog OR 0.62, 95% CI [0.39;0.98], 2nd yearany pet OR 0.74, 95% CI [0.57;0.97], 2nd yeardog OR 0.63, 95% CI [0.40;0.98]). Ownership of small furred pets (hamster, rabbit and guinea pig) also showed a borderline protective effect for the 1st year. We assume an association between keeping pets and undefined environmental factor(s) that contribute protectively to the development of atopic dermatitis in early life, presumably by effects on the maturation of the immune system.
影响因子：
158.5
作者：
Ball, TM;Castro-Rodriguez, JA;Wright, AL
通讯作者：
Wright, AL