Perspectives on the therapeutic potential of short-chain fatty acid receptors.
Perspectives on the therapeutic potential of short-chain fatty acid receptors.
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DOI：
10.5483/bmbrep.2014.47.3.272
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发表时间：
2014-03
期刊：
影响因子：
3.8
通讯作者：
Kwak YS
中科院分区：
文献类型：
--
作者：
Kim S;Kim JH;Park BO;Kwak YS
人们对人类微生物组的兴趣迅速增长，因为它与代谢紊乱和炎症性疾病有关。因此，了解短链脂肪酸及其受体的生物学对于确定新的治疗途径变得非常重要。GPR 41和GPR 43被认为是SCFAs的同源受体，其在代谢和炎症中的作用近年来受到了广泛关注。GPR 43在免疫细胞上高度表达，并已被认为在炎性疾病如炎性肠病中发挥作用。GPR 41和GPR 43都通过调节脂肪组织和胃肠激素参与糖尿病和肥胖症。到目前为止，许多研究提供了相互矛盾的结果，因此需要进一步的研究来验证这些受体作为药物靶点。我们还将讨论GPR 41和GPR 43的合成调节剂，这对理解这些受体的功能至关重要。[BMB报告2014; 47（3）：173-178]
There is rapidly growing interest in the human microbiome because of its implication in metabolic disorders and inflammatory diseases. Consequently, understanding the biology of short chain fatty acids and their receptors has become very important for identifying novel therapeutic avenues. GPR41 and GPR43 have been recognized as the cognate receptors for SCFAs and their roles in metabolism and inflammation have drawn much attention in recent years. GPR43 is highly expressed on immune cells and has been suggested to play a role in inflammatory diseases such as inflammatory bowel disease. Both GPR41 and GPR43 have been implicated in diabetes and obesity via the regulation of adipose tissue and gastrointestinal hormones. So far, many studies have provided contradictory results, and therefore further research is required to validate these receptors as drug targets. We will also discuss the synthetic modulators of GPR41 and GPR43 that are critical to understanding the functions of these receptors. [BMB Reports 2014; 47(3): 173-178]
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