Cortical electric response audiometry hearing threshold estimation: Accuracy, speed, and the effects of stimulus presentation features
Cortical electric response audiometry hearing threshold estimation: Accuracy, speed, and the effects of stimulus presentation features
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DOI：
10.1097/01.aud.0000233902.53432.48
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发表时间：
2006-10-01
期刊：
影响因子：
3.7
通讯作者：
Kennedy, Vicki
中科院分区：
文献类型：
--
作者：
Lightfoot, Guy;Kennedy, Vicki
目的：研究了突发音调诱发的 N1-P2 皮层反应的许多刺激呈现特征，以确定当该测试用于听力阈值估计时相对于简单刺激的任何优势。还通过设计有效的测试方案来测量双耳在 1、3 和 8 kHz 处建立客观阈值的速度，以及参考受试者的传统听力图进行阈值估计的精度。 设计：招募了 24 名志愿者受试者，并通过行为和电生理学方法进行测试。研究刺激特征时使用低强度 3 kHz 刺激。参数是 N1-P2 振幅。结果：改变呈现的一侧（随机或通过交替耳朵）、改变刺激间隔并在中途插入 10 秒恢复期，尽管平均运行对响应振幅没有明显影响，无论是单独还是组合，这与早期的报告相反。建立 6 个阈值估计平均需要 20.6 分钟。 N1-P2 阈值估计的平均误差为 6.5 dB，频率没有显着影响。纠正这种偏差后，94% 的个体阈值估计在行为阈值的 15 dB 以内，80% 在 10 dB 以内。结论：这项研究表明，皮层电反应测听法的性能与成人阈值估计的听觉脑干反应一样好或更好，并且似乎不需要复杂的刺激技术。一个有效的测试协议可以自动执行许多繁重的任务，将测试时间减少到之前文献中针对此响应报告的一半以下。
Objectives: A number of stimulus presentation features of the tone burst-evoked N1-P2 cortical response were investigated to identify any advantage over simple stimulation when the test is used for hearing threshold estimation. The speed of establishing objective thresholds at 1, 3, and 8 kHz in both ears was also measured in what was designed to be an efficient test protocol, together with the precision of the threshold estimates with reference to subjects' conventional audiograms.Design: Twenty-four volunteer subjects were recruited and tested by both behavioral and electrophysiological methods. A low-intensity, 3-kHz stimulus was used when the stimulus features were studied. The parameter was the N1-P2 amplitude.Results: Changing the side of presentation (randomly or by alternating ears), varying the interstimulus interval and inserting a 10-second recovery period midway though an averaging run had no demonstrable effect on response amplitude, both individually or in combination, contrary to earlier reports. Establishing the 6 threshold estimates took an average 20.6 minutes. The mean error in the N1-P2 threshold estimate was 6.5 dB, with no significant effect of frequency. After correcting for this bias, 94% of individual threshold estimates were within 15 dB of the behavioral threshold and 80% were within 10 dB.Conclusions: This study suggests that cortical electric response audiometry has a performance that is as good as or better than the auditory brain stem response for threshold estimation in adults and that sophisticated stimulation techniques do not appear to be required. An efficient test protocol that automates many laborious tasks reduces the test time to less than half that previously reported in the literature for this response.