Pathological features of intestinal T‐cell lymphoma in Shiba dogs in Japan
Pathological features of intestinal T‐cell lymphoma in Shiba dogs in Japan
复制标题
日本柴犬肠道T细胞淋巴瘤的病理特征
DOI：
10.1111/vco.12396
复制
发表时间：
2018
影响因子：
2.1
通讯作者：
H.
中科院分区：
文献类型：
--
作者：
Matsumoto I.;Uchida;K.;Nakashima;K.;Goto-Koshino;Y.;Chambers;J.;Tsujimoto;H. and Nakayama;H.
由于兽医学中内窥镜检查和克隆性分析的广泛应用，犬肠道 T 细胞淋巴瘤的诊断越来越频繁。然而，此前尚未对肠道T细胞淋巴瘤进行流行病学研究，因此，有关肠道T细胞淋巴瘤的狗品种、年龄和性别分布的信息在很大程度上仍不清楚。在这项研究中，通过计算比值比和 95% 保密区间来确定犬肠道 T 细胞淋巴瘤的品种易感性。在已确定的 43 个品种中，有 7 个品种患肠道 T 细胞淋巴瘤的风险似乎增加，包括柴犬、德国牧羊犬、凯恩梗、波士顿梗、蝴蝶犬、哈巴狗和马耳他犬。代表性柴犬病例的免疫组织化学揭示了大细胞淋巴瘤和小细胞淋巴瘤中普遍存在的细胞毒性免疫表型。有趣的是，在 11% 的病例中观察到 CD20 共表达。这可能是 CD20 的异常表达或正常 CD20 阳性 T 细胞亚群的肿瘤转化。对代表性品种之间的平均年龄进行比较表明，柴犬比迷你腊肠犬稍年轻（P < .05）。然而，这两个品种的生存率没有差异。由于柴犬容易患慢性肠病，因此可能存在潜在的炎症过程，导致该品种肠道 T 细胞淋巴瘤的发生。我们的研究结果为了解品种特异性犬肠道 T 细胞淋巴瘤的潜在发病机制提供了见解。
Intestinal T‐cell lymphoma is being more frequently diagnosed in dogs owing to the wide availability of endoscopy and clonality analysis in veterinary medicine. However, no epidemiological study on intestinal T‐cell lymphoma has been previously performed, and hence, information about dog breed, age and sex distributions of intestinal T‐cell lymphoma has largely remained unclear. In this study, breed predisposition to canine intestinal T‐cell lymphoma was determined by calculating odds ratios and 95% confidential intervals. Of the 43 breeds identified, 7 appeared to have an increased risk of developing intestinal T‐cell lymphoma, including Shiba dogs, German shepherds, Cairn terriers, Boston terriers, Papillons, Pugs and Maltese. Immunohistochemistry of representative Shiba cases revealed ubiquitous cytotoxic immunophenotype in both large and small cell lymphomas. Interestingly, CD20 co‐expression was observed in 11% of cases. It could potentially be aberrant expression of CD20 or neoplastic transformation of a normal subset of CD20‐positive T‐cells. A comparison of mean age between representative breeds revealed that Shiba dogs were slightly younger than Miniature Dachshunds (P< .05). However, there was no difference in survival between the 2 breeds. As Shiba dogs are predisposed to chronic enteropathy, there may be underlying inflammatory process contributing to lymphomagenesis of intestinal T‐cell lymphoma in this breed. Our findings provide insights into the underlying pathogenesis of breed‐specific canine intestinal T‐cell lymphoma.