DNA Modification by the Nitrosoureas: Chemical Nature and Cellular Repair

DNA Modification by the Nitrosoureas: Chemical Nature and Cellular Repair
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亚硝基脲对 DNA 的修饰:化学性质和细胞修复

DOI:
10.1007/978-1-4613-2563-5_6
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发表时间:
1985
影响因子:
3.1
通讯作者:
W. Tong
W. Tong
中科院分区:
生物学4区
文献类型:
--
作者:
D. Ludlum;W. Tong

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与DNA发生反应的化合物,有很多,是我们最有效的抗肿瘤药物之一。事实上,氮芥及其衍生物的使用开启了有效癌症化疗的时代。从那时起,人们积累了大量关于抗肿瘤药物与DNA相互作用的信息,并对其作用机制提出了一些基本假设。
Compounds which react with DNA, and there are many, rank with our most effective antitumor agents. In fact, the use of nitrogen mustard and its derivatives introduced the era of effective cancer chemotherapy. Since that time, a wealth of information has accumulated about the interaction of antineoplastic agents with DNA, and certain basic hypotheses have been developed about their mechanism of action.
DOI: 10.1016/0006-2952(83)90420-3
发表时间: 1983
影响因子: 5.8
作者:
Tong,WP;Kirk,MC;Ludlum,DB
通讯作者: Ludlum,DB