Differential effects of prenatal stress on the morphological maturation of hippocampal neurons
Differential effects of prenatal stress on the morphological maturation of hippocampal neurons
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DOI：
10.1016/j.neuroscience.2006.04.046
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发表时间：
2006-01-01
期刊：
影响因子：
3.3
通讯作者：
Nakamura, S.
中科院分区：
文献类型：
--
作者：
Fujioka, A.;Fujioka, T.;Nakamura, S.
本研究旨在阐明产前应激对大鼠海马神经元形态发育的强度依赖性影响。此外，糖皮质激素受体（即矿化皮质激素受体和糖皮质激素受体）参与应激诱导海马神经元形态变化的体外药理学方法进行了研究。轻度产前应激对成年后代海马神经发生和长期增强的影响也进行了研究。产前应激对海马形态发育的影响呈强度依赖性。短期、轻度的产前应激增强了新生儿海马神经元的神经发生和分化过程，而长期、严重的产前应激则损害了它们的形态。发现矿化皮质激素受体介导海马神经元的神经发生和分化。糖皮质激素受体参与了对其形态的抑制。短期的、温和的产前压力，先前已被证明可以提高成年后代的学习表现，促进神经发生和成年海马的长期增强。这些结果表明，产前应激对海马神经元的发育有不同程度的促进和抑制作用，矿皮质激素受体和糖皮质激素受体参与了应激诱导的形态变化。(c) 2006 IBRO。Elsevier Ltd.出版。版权所有。
The present study was designed to clarify an intensity-dependent effect of prenatal stress on the morphological development of hippocampal neurons in rats. In addition, the involvement of receptors for glucocorticoids, i.e. mineralocorticoid receptors and glucocorticoid receptors, in stress-induced changes in the morphology of hippocampal neurons was examined by an in vitro pharmacological approach. The effects of mild prenatal stress on neurogenesis and long-term potentiation in the hippocampus were also investigated in adult offspring. Prenatal stress affected the morphological development of the hippocampus in an intensity-dependent manner. Short-lasting, mild prenatal stress enhanced neonatal neurogenesis and differentiation of processes of hippocampal neurons, whereas long-lasting, severe stress impaired their morphology. Mineralocorticoid receptor was found to mediate enhancement of neurogenesis and differentiation of processes of cultured hippocampal neurons. In contrast, glucocorticoid receptor was involved in the suppression of their morphology. Short-lasting, mild prenatal stress, which has previously been shown to enhance learning performance in adult offspring, facilitated neurogenesis and long-term potentiation in the adult hippocampus.These findings suggest that prenatal stress has enhancing and suppressing effects on the development of hippocampal neurons depending on intensity, and that mineralocorticoid receptors and glucocorticoid receptors contribute to stress-induced morphological changes. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.