Quantifying vascular density and morphology using different swept-source optical coherence tomography angiographic scan patterns in diabetic retinopathy
Quantifying vascular density and morphology using different swept-source optical coherence tomography angiographic scan patterns in diabetic retinopathy
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DOI：
10.1136/bjophthalmol-2018-311942
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发表时间：
2019-02-01
影响因子：
4.1
通讯作者：
Sadda, Srinivas
中科院分区：
文献类型：
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作者：
Hirano, Takao;Kitahara, Jyunya;Sadda, Srinivas
目的应用不同大小的En面部扫描源光学相干断层扫描血管成像(SS-OCTA)图像评价糖尿病视网膜病变(DR)患者视网膜微血管的定量指标。方法使用SS-OCTA设备(PLEX Elite 9000；Carl Zeiss Meditec，Dublin，California，USA)获取非分割和分割图像。扫描方案包括3x3 mm、6x6 mm和12x12 mm视野。对血流灌注密度(PD)、血管长度密度(VLD)和分维(FD)进行定量分析。结果前瞻性横断面研究包括46例(60眼)糖尿病患者和16例(21眼)正常人的60眼(非DR 13眼；非增殖性DR(NPDR)24眼；增殖性DR(PDR)23眼)。在12×12 mm的图像上，健康人的PD在所有层面上都明显大于NPDR和PDR患者(P
Aims To evaluate quantitative metrics of the retinal microvasculature in eyes with diabetic retinopathy (DR) using various en face swept-source optical coherence tomography angiography (SS-OCTA) image sizes. Methods Non-segmented and segmented images were acquired using an SS-OCTA device (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, California, USA). The scanning protocols included the 3x3 mm, 6x6 mm and 12x12 mm fields of view. Quantitative analysis of the perfusion density (PD), vessel length density (VLD) and fractal dimension (FD) was performed. The area under the receiver operating characteristic curve was estimated to assess the ability of each image size to predict DR. Results This prospective, cross-sectional study included 60 eyes, (non-DR, 13 eyes; non-proliferative DR (NPDR), 24 eyes; proliferative DR (PDR), 23 eyes) of 46 patients with diabetes and 21 eyes of 16 healthy individuals. In the 12x12 mm images, the PD of healthy individuals was significantly greater than that of patients with NPDR or PDR for all layers (NPDR, p