Highly enantioselective synthesis of chiral imides and derived products via chiral base desymmetrisation
Highly enantioselective synthesis of chiral imides and derived products via chiral base desymmetrisation
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DOI：
10.1016/s0040-4020(02)00367-8
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发表时间：
2002-06-03
期刊：
影响因子：
2.1
通讯作者：
Simpkins, NS
中科院分区：
文献类型：
--
作者：
Adams, DJ;Blake, AJ;Simpkins, NS
几种环融合亚胺与手性碱的对映选择性去质子化，然后亲电猝灭，得到一系列手性产物，收率高，ee大于或等于91%。用x射线晶体学测定了两种产物的绝对立体化学性质。许多亚胺产物经受了进一步的、高度区域选择性的转化，包括烯酸酯取代、还原和硫代化。(C) 2002年Elsevier Science Ltd.出版
The enantioselective deprotonation of several ring-fused imides with a chiral base, followed by electrophilic quenching, gives a range of chiral products in good yield and in greater than or equal to91% ee. The absolute stereochemistry of two of the products was determined by X-ray crystallography. A number of the imide products were subjected to further, highly regioselective, transformations, including enolate substitution, reduction and thionation. (C) 2002 Published by Elsevier Science Ltd.