Areolar Sebaceous Hyperplasia With Underlying Primary Duct Carcinoma of the Breast in a Woman With Donohue Syndrome (Leprechaunism)
Areolar Sebaceous Hyperplasia With Underlying Primary Duct Carcinoma of the Breast in a Woman With Donohue Syndrome (Leprechaunism)
复制标题
DOI：
10.1097/dad.0b013e318231311a
复制
发表时间：
2012-04-01
影响因子：
1.1
通讯作者：
Rodriguez-Cernuda, Purificacion
中科院分区：
文献类型：
--
作者：
Fernandez-Flores, Angel;Valerdiz, Saul;Rodriguez-Cernuda, Purificacion
乳晕增生仅在过度增生时报告，即使如此，过度的乳晕皮脂腺增生也很罕见。我们最近看到一例32岁女性多诺休综合征（矮妖症）的乳晕状皮脂腺增生，她在同一个乳房也有浸润性导管癌。患者表现出典型的“精灵般”的脸，鼻孔宽，嘴唇厚，大而低的耳朵，和发育不良的指甲。乳晕显示直径为5 cm的黄色增厚斑块，对应于皮脂腺增生。错配修复蛋白（MLH1，MSH2，MSH6和PMS2）的免疫组织化学进行了皮脂腺增生和乳腺癌，并没有缺乏的标志物的表达被证明。我们没有发现其他报告的情况下，乳晕皮脂腺增生的情况下，乳腺癌或矮妖精。
Areolar hyperplasia is only reported when exaggerated, and even so, exaggerated areolar sebaceous hyperplasia is rare. We have recently seen a case of areolar sebaceous hyperplasia in a 32-year-old woman with Donohue syndrome (leprechaunism), who also had an invasive ductal carcinoma in the same breast. The patient showed typical "elfin-like'' face with wide nostrils and thick lips, large and low-set ears, and dysplastic nails. The areola showed a yellowish thickened plaque of 5-cm diameter that corresponded to a hyperplasia of the sebaceous glands. Immunohistochemistry for the mismatch repair proteins (MLH1, MSH2, MSH6, and PMS2) was performed on the sebaceous hyperplasia and on the breast carcinoma, and no lack of expression of the markers was evidenced. We have found no other reported case of areolar sebaceous hyperplasia either in cases of breast carcinoma or in cases of leprechaunism.