Enteric neuronal density contributes to the severity of intestinal inflammation.
Enteric neuronal density contributes to the severity of intestinal inflammation.
复制标题
DOI：
10.1053/j.gastro.2011.04.047
复制
发表时间：
2011-08
期刊：
影响因子：
29.4
通讯作者：
Gershon MD
中科院分区：
文献类型：
--
作者：
Margolis KG;Stevanovic K;Karamooz N;Li ZS;Ahuja A;D'Autréaux F;Saurman V;Chalazonitis A;Gershon MD
Enteric neurons have been reported to be increased in inflamed regions of the bowel in patients with inflammatory bowel disease (IBD) or intestinal neurogangliomatosis. It is impossible to determine whether this hyperinnervation predates intestinal inflammation, results from it, or contributes to its severity in humans, so we studied this process in mice. To determine whether the density of enteric neurons determines the severity of inflammation, we studied transgenic mice that have greater-than-normal (Hand2+/− mice) or fewer-than-normal (NSE-noggin mice, which overexpress noggin under the control of the neuron-specific enolase promoter) numbers of neurons in the enteric nervous system (ENS). Colitis was induced with trinitrobenzene sulfonic acid or dextran sulfate sodium and the intensity of the resulting inflammation in Hand2+/− and NSE-noggin mice was compared with that of wild-type littermates. Severity of each form of colitis (based on survival, symptom, and histologic scores; intestinal expression of genes that encode proinflammatory molecules; and levels of neutrophil elastase and p50 NF- Hand2+/− mice and significantly increased in NSE-noggin animals. Neither mouse differed from wild-type in the severity of delayed-type hypersensitivity (edema, T-cell and neutrophil infiltration, or expression of interleukin- - - -dinitro-1-fluorobenzene. Transgene effects on inflammation were therefore restricted to the gastrointestinal tract. The severity of intestinal inflammation is associated with the density of the enteric innervation in mice. Abnormalities in ENS development might therefore contribute to the pathogenesis of IBD.
登录
查看更多内容
影响因子：
6.7
作者：
Axelsson, LG;Landstrom, E;BylundFellenius, AC
通讯作者：
BylundFellenius, AC
影响因子：
2.5
作者：
Morikawa, Y;Dai, YS;Cserjesi, P
通讯作者：
Cserjesi, P
DOI：
10.1523/jneurosci.1145-09.2009
发表时间：
2009-08-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Liu MT;Kuan YH;Wang J;Hen R;Gershon MD
通讯作者：
Gershon MD
影响因子：
3.5
作者：
Haub S;Ritze Y;Bergheim I;Pabst O;Gershon MD;Bischoff SC
通讯作者：
Bischoff SC
影响因子：
2.7
作者：
Hendershot, Tyler J.;Liu, Hongbin;Howard, Marthe J.
通讯作者：
Howard, Marthe J.