A vaccine against Asian schistosomiasis: the story unfolds
A vaccine against Asian schistosomiasis: the story unfolds
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DOI：
10.1016/s0020-7519(99)00200-3
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发表时间：
2000-03-01
影响因子：
4
通讯作者：
McManus, DP
中科院分区：
文献类型：
--
作者：
McManus, DP
针对亚洲血吸虫的有效疫苗的研制正处于关键阶段。尽管进展相对缓慢，但减毒疫苗在动物身上的成功使用，加上最近使用明确的本土和重组衍生日本血吸虫抗原取得的令人鼓舞的结果，表明开发安全有效的疫苗是可行的。本综述审查了目前在实现这一目标方面取得的进展，并概述了最近使用最令人鼓舞的疫苗抗原取得的结果。当疫苗可以广泛使用时，预计将首先应用于兽医领域（对人类传播的影响），然后，如果需要，可能会应用于临床（预防或减少疾病），至少在中国是这样。寻找最终产品可能是艰巨的，并且需要解决与良好生产规范有关的资金问题——扩大疫苗规模以满足所需的广泛兽医覆盖范围，并支持任何未来的人体试验。因此，我们可能还需要等待一段时间才能研制出最终的疫苗，这种疫苗可能包括几种分子的混合物。即便如此，该疫苗也可能被最佳地用作血吸虫病中心综合规划的一个组成部分，该规划将包括有效和经过充分测试的方法，如健康教育和靶向化疗。(C) 2000澳大利亚寄生虫学学会Elsevier Science Ltd.出版。版权所有。
The development of an effective vaccine against the Asian schistosome is at a critical stage. Despite the fact that progress has been relatively slow, the successful use in animals of attenuated Vaccines combined with recent encouraging results using defined native and recombinantly derived Schistosoma japonicum antigens, suggests that development of a safe and effective vaccine is feasible. This review examines current progress aimed at achieving this objective, and a summary is provided of recent results obtained with the most encouraging vaccine antigens. When available for wide-scare use, it is envisaged that the Vaccine would be applied in the first instance, at least in China, in the veterinary context (to impact on human transmission) and then, perhaps, if required, clinically (to prevent or reduce disease). The search for the final product is likely to be demanding, and funding issues pertaining to Good Manufacturing Practice-scale-up of the vaccine for the required extensive veterinary coverage, and to support any future human trials, will need to be resolved. As such, we may still have to wait some time before the ultimate vaccine, possibly comprising a cocktail of several molecules, is available. Even then, the Vaccine would probably be used optimally as one component of an integrated programme of schistosomiasis central that would include effective and well-tested approaches, such as health education and targeted chemotherapy. (C) 2000 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.