Withania somnifera: From prevention to treatment of cancer.
Withania somnifera: From prevention to treatment of cancer.
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DOI：
10.1002/mnfr.201500756
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发表时间：
2016-06
影响因子：
5.2
通讯作者：
Kensler TW
中科院分区：
文献类型：
--
作者：
Palliyaguru DL;Singh SV;Kensler TW
具有潜在阻断致癌作用的生物活性分子的鉴定继续获得研究兴趣。特别地，具有膳食来源的分子由于其安全性、成本效益和口服施用的可行性而最有吸引力。多年来，营养保健品在人类的整体福祉中发挥了重要作用，无论是否有严格的证据支持其健康声明。世界各地的传统医学系统数千年来一直利用具有药用特性的植物，为现代研究人员提供了评估其对癌症等疾病的功效的机会。Withania somnifera（WS）是一种用于Ayurveda（亚洲一种古老的医学形式）的植物，最近在实验模型中已被证明具有抗肿瘤特性。虽然在过去十年中对WS进行的科学研究已经爆炸，但有关作用模式和所涉及的分子靶点的许多内容仍然未知。在这篇综述中，我们讨论了植物的传统用途，支持其化学预防潜力的实验证据，以及需要克服的障碍，以WS被评估为人类的化学预防剂。
The identification of bioactive molecules that have potential to interrupt carcinogenesis continues to garner research interest. In particular, molecules that have dietary origin are most attractive because of their safety, cost-effectiveness and feasibility of oral administration. Nutraceuticals have played an important role in the overall well-being of humans for many years, with or without rigorous evidence backing their health claims. Traditional medicine systems around the world have utilized plants for millennia that have medicinal properties, providing an opportunity for modern day researchers to assess their efficacies against ailments such as cancer. Withania somnifera (WS) is a plant that has been used in Ayurveda (an ancient form of medicine in Asia) and in the recent past, has been demonstrated to have anti-tumorigenic properties in experimental models. While scientific research performed on WS has exploded in the past decade, much regarding the mode of action and molecular targets involved remains unknown. In this review, we discuss the traditional uses of the plant, the experimental evidence supporting its chemopreventive potential as well as roadblocks that need to be overcome in order for WS to be evaluated as a chemopreventive agent in humans.