HIV-1 incorporates ABO histo-blood group antigens that sensitize virions to complement-mediated inactivation
HIV-1 incorporates ABO histo-blood group antigens that sensitize virions to complement-mediated inactivation
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DOI：
10.1182/blood-2004-11-4267
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发表时间：
2005-06-15
期刊：
影响因子：
20.3
通讯作者：
Weiss, RA
中科院分区：
文献类型：
--
作者：
Neil, SJD;McKnight, A;Weiss, RA
ABO 组织血型抗原被认为可以通过天然抗体和补体的作用来改变病原体的传播。抗原由由 2 个显性活性等位基因和一个隐性无活性等位基因编码的多态性糖基转移酶产生。在这项研究中，我们研究了 ABO 糖是否掺入 HIV-1 病毒粒子的包膜中。来自表达 ABO 抗原的细胞的 HIV 载体表现出对新鲜人血清的敏感性，类似于 ABO 不相容性，并且在病毒包膜蛋白糖蛋白 120 (gp120) 上检测到 ABO 组织血型糖。此外，淋巴细胞来源的病毒还表现出血清敏感性，在自体血清中培养时，由于抗原吸附到细胞表面，反映了宿主的ABO表型。血清敏感性需要活性补体和特异性抗 ABO 抗体。因此，HIV-1掺入ABO抗原可能通过与宿主天然抗体和补体的相互作用影响病毒在血型不一致的个体之间的传播。 (c) 2005 年，美国血液学会。
ABO histo-blood group antigens have been postulated to modify pathogen spread through the action of natural antibodies and complement. The antigens are generated by a polymorphic glycosyltransferase encoded by 2 dominant active and a recessive inactive allele. In this study we investigated whether ABO sugars are incorporated into the envelope of HIV-1 virions. HIV vectors derived from cells expressing ABO antigens displayed sensitivity to fresh human serum analogous to ABO incompatibility, and ABO histo-blood group sugars were detected on the viral envelope protein, glycoprotein 120 (gp120). Moreover, lymphocyte-derived virus also displayed serum sensitivity, reflecting the ABO phenotype of the host when cultured in autologous serum due to adsorption of antigens to cell surfaces. Serum sensitivity required both active complement and specific anti-ABO antibodies. Thus, incorporation of ABO antigens by HIV-1 may affect transmission of virus between individuals of discordant blood groups by interaction with host natural antibody and complement. (c) 2005 by The American Society of Hematology.