Association of parity with risk of type 2 diabetes and related metabolic disorders
Association of parity with risk of type 2 diabetes and related metabolic disorders
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DOI：
10.2337/diacare.25.4.690
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发表时间：
2002-04-01
期刊：
影响因子：
16.2
通讯作者：
Zinman, B
中科院分区：
文献类型：
--
作者：
Hanley, AJG;McKeown-Eyssen, G;Zinman, B
目的：胎次与糖尿病风险之间的关系是有争议的，关于胎次与胰岛素抵抗和p细胞功能之间的关系的信息很少。本研究的目的是调查胎次与葡萄糖耐受不良和相关代谢紊乱风险之间的关系，研究数据来自加拿大原住民社区的一项基于人群的研究。研究设计和方法-女性参与者（n = 383，年龄12-79岁）提供空腹血液样本，用于测定葡萄糖、胰岛素、c肽和胰岛素原浓度。给予75克口服葡萄糖耐量试验，并根据世界卫生组织的标准诊断糖尿病和糖耐量受损。测量腰围和体脂百分比。有关活产的发生和以前诊断的糖尿病的信息是从访谈者管理的问卷中获得的。结果：调整饲草量和腰围后，胎次与糖尿病风险显著降低相关（未产子vs 1产子，优势比0.43,95% CI 0.19-0.94, P < 0.05）。此外，在年龄和腰围调整后的分析中，非糖尿病未生育妇女的空腹胰岛素和胰岛素原浓度明显高于非糖尿病未生育妇女（均P < 0.05）。结论：我们的结果与其他糖尿病高发人群的结果一致，表明在该人群的未生育亚队列中存在糖尿病易感表型，可能导致不孕。
OBJECTIVE - The relationship between parity and risk of diabetes is controversial, and little information is available regarding associations between parity and measures of insulin resistance and P-cell function. The objective of this study was to investigate the association between parity and risk of glucose intolerance and related metabolic disorders using data from a population-based stud), in a Native Canadian community.RESEARCH DESIGN AND METHODS - Female participants (n = 383, aged 12-79 years) provided fasting blood samples for the determination of glucose, insulin, C-peptide, and proinsulin concentrations. A 75-g oral glucose tolerance test Was administered, and diabetes and impaired glucose tolerance were diagnosed according to World Health Organization criteria. Waist circumference and percent body fat were determined. Information regarding occurrence of live births and previously diagnosed diabetes was obtained from inter-viewer-administered questionnaires.RESULTS - Parity was associated with a significantly reduced risk of diabetes (nulliparous vs. a I birth, odds ratio 0.43, 95% CI 0.19-0.94, P < 0.05) after adjustment forage and waist circumference. In addition, nondiabetic nulliparous women had significantly elevated concentrations of fasting insulin and proinsulin relative to nondiabetic parous women (all P < 0.05) in analyses adjusted for age and waist circumference,CONCLUSIONS - Our results are consistent with those from other populations experiencing high rates of diabetes and suggest the presence of a diabetes-prone phenotype within the nulliparous subcohort of this population, which may contribute to infertility.