A shortened Stroop test to identify covert hepatic encephalopathy and predict overt hepatic encephalopathy in patients with cirrhosis
A shortened Stroop test to identify covert hepatic encephalopathy and predict overt hepatic encephalopathy in patients with cirrhosis
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用于识别隐性肝性脑病并预测肝硬化患者显性肝性脑病的缩短斯特鲁普试验
DOI：
10.1007/s00535-022-01925-0
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发表时间：
2022
影响因子：
6.3
通讯作者：
Shimizu Masahito
中科院分区：
文献类型：
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作者：
Hanai Tatsunori;Nishimura Kayoko;Miwa Takao;Maeda Toshihide;Nakahata Yuki;Imai Kenji;Suetsugu Atsushi;Takai Koji;Shimizu Masahito
隐匿性肝性脑病(ChE)对肝硬变患者的临床预后有不利影响，但仍有很大程度上未得到诊断和治疗。虽然Stroop试验是检测CHE的一种有用的方法，但诊断CHE需要更快、更简单、更准确的测试。这项前瞻性研究旨在开发一种新的简化Stroop试验，以检测CHE并预测日本肝硬变患者的临床肝性脑病(OHE)。方法对2018年11月至2021年12月接受神经心理测试(NPT)和Stroop试验的患者进行跟踪观察，直到OHE发生或2022年3月。结果在2 2 7例符合条件的患者中，ON1-2 TIME分界值为44.4，与总Stroop试验时间的判别能力相当，AUC值为0.791，灵敏度为0.827，特异度为0.685。在16个月的中位随访期内，37名患者发生了OHE。On 1-2Time Stroop试验(On 1-2Time)、S(危险比[HR]3.93；95%可信区间[CI]1.36-11.36)和血清白蛋白水平(HR，0.28；95%CI0.11-0.67)与OHE的发生独立相关。结论缩短 ≥ 试验(On 1-2Time)不仅可用于识别CHE，而且可用于估计进展为OHE的危险性。
BackgroundCovert hepatic encephalopathy (CHE) adversely affects the clinical outcomes of patients with cirrhosis but remains largely undiagnosed and untreated. Although the Stroop test is a useful method for CHE detection, a faster, simpler, and more accurate test is required to diagnose CHE. This prospective study aimed to develop a new shortened Stroop test that can detect CHE and predict overt hepatic encephalopathy (OHE) in Japanese patients with cirrhosis.MethodsPatients who underwent neuropsychological tests (NPT) and the Stroop test between November 2018 and December 2021 were enrolled and followed until OHE occurrence or March 2022. The discriminative ability of various run combinations in the off and on states to detect CHE was evaluated using the area under the receiver-operating characteristic curve (AUC) and compared with that of the total Stroop test time.ResultsAmong the 227 eligible patients, the On1–2Time cutoff value of 44.4 s had a comparable discriminative ability with the total Stroop test time to detect CHE, with an AUC of 0.791, a sensitivity of 0.827, and a specificity of 0.685. During a median follow-up period of 16 months, 37 patients developed OHE. On1–2Time ≥ 44.4 s (hazard ratio [HR], 3.93; 95% confidence interval [CI] 1.36–11.36) and serum albumin levels (HR, 0.28; 95% CI 0.11–0.67) were independently associated with OHE occurrence.ConclusionsThe shortened Stroop test (On1–2Time) is equivalent to the total Stroop test not only for identifying CHE but also for estimating the risk of progression to OHE.
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影响因子：
12.6
作者：
Bajaj, Jasmohan S.;Heuman, Douglas M.;Sterling, Richard K.;Sanyal, Arun J.;Siddiqui, Muhammad;Matherly, Scott;Luketic, Velimir;Stravitz, R. Todd;Fuchs, Michael;Thacker, Leroy R.;Gilles, HoChong;White, Melanie B.;Unser, Ariel;Hovermale, James;Gavis, Edith;Noble, Nicole A.;Wade, James B.
通讯作者：
Wade, James B.
验证 EncephalApp_Stroop 作为检测德国肝硬化患者轻微肝性脑病的筛查工具。
DOI：
10.1016/j.clinre.2022.101873
发表时间：
2022
影响因子：
2.7
作者：
L. Kaps;Katharina Hildebrand;M. Nagel;M. Michel;W. Kremer;M. Hilscher;P. Galle;J. Schattenberg;M. Wörns;C. Labenz
通讯作者：
C. Labenz
影响因子：
3.8
作者：
Cunha-Silva, Marlone;Ponte Neto, Fernando L.;Mazo, Daniel F.
通讯作者：
Mazo, Daniel F.
影响因子：
9.8
作者：
Patidar, Kavish R.;Thacker, Leroy R.;Wade, James B.;Sterling, Richard K.;Sanyal, Arun J.;Siddiqui, Mohammad S.;Matherly, Scott C.;Stravitz, R. Todd;Puri, Puneet;Luketic, Velimir A.;Fuchs, Michael;White, Melanie B.;Noble, Nicole A.;Unser, Ariel B.;Gilles, HoChong;Heuman, Douglas M.;Bajaj, Jasmohan S.
通讯作者：
Bajaj, Jasmohan S.
EncephalApp Stroop App预测乙型肝炎诱发的肝硬化导致的轻微肝性脑病患者睡眠质量较差
DOI：
10.4103/sjg.sjg_558_19
发表时间：
2020
期刊：
Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association
影响因子：
--
作者：
Ming Luo;Xiao;Sheng;Fei
通讯作者：
Fei