Genetic association between agouti locus and adrenal X zone morphology in SM/J mice.
Genetic association between agouti locus and adrenal X zone morphology in SM/J mice.
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SM/J 小鼠刺鼠基因座与肾上腺 X 区形态之间的遗传关联。
DOI：
10.1159/000147573
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
A. Matsuzawa
中科院分区：
文献类型：
--
作者：
S. Tanaka;M. Nishimura;A. Matsuzawa
我们为分离性近交系小鼠SM/J的2号染色体上的agouti (a)位点与肾上腺皮质X区之间的遗传联系提供了证据。该菌株是在a位点保持杂合性（Aw/a）的情况下建立和维持的，因此在评估这些等位基因对生理现象的影响方面具有优势。在Aw/a（白腹田鼠）或a/a（黑田鼠）中，X区完全由非空泡细胞组成，而它们仅在Aw/Aw中含有空泡细胞。这表明在SM/J遗传背景下，a基因座可能控制X区形态，而a （nonagouti）等位基因在该区细胞的空泡形成中占主导地位。除了已知的控制毛色的功能外，a位点可能在控制肾上腺皮质X区细胞更新方面具有新的功能。
We provide evidence for a genetic link between the adrenocortical X zone and the agouti (a) locus on chromosome 2 in the segregating inbred mouse strain SM/J. This strain has been established and maintained while keeping heterozygosity (Aw/a) at the a locus and is, therefore, of advantage in assessing the effects of these alleles upon physiological phenomena. In Aw/a (white-bellied agouti) or a/a (black) virgins, X zones were composed exclusively of nonvacuolated cells, while they contained vacuolated cells only in Aw/Aw. This suggested that the a locus might control the X zone morphology on the SM/J genetic background and that the a (nonagouti) allele is dominant in vacuolation of cells in this zone. The a locus might have a novel function in the control of the adrenocortical X zone cell turnover in addition to the well-known function controlling the coat color.