Recent developments in silicones for topical and transdermal drug delivery
Recent developments in silicones for topical and transdermal drug delivery
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DOI：
10.4155/tde.15.39
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发表时间：
2015-07-01
影响因子：
4.2
通讯作者：
Schalau, Gerald, III
中科院分区：
文献类型：
--
作者：
Aliyar, Hyder;Schalau, Gerald, III
有机硅用于药品、化妆品和医疗器械已有 60 多年的历史。聚二甲基硅氧烷是通常用作口服药物产品中的活性剂或用作局部和透皮药物产品中的赋形剂的聚合物。疏水性、附着力和美观等固有特性使有机硅能够为药品提供功能和性能。溶胀交联有机硅弹性体共混网络、糖硅氧烷、两亲性树脂线性聚合物和有机硅混合压敏粘合剂等最新技术有望带来潜在的性能优势并提高药物输送功效。本文综述了有机硅材料的最新发展，重点关注其作为赋形剂影响局部和透皮系统药物输送的功能。
Silicones have been used in medicines, cosmetics and medical devices for over 60 years. Polydimethylsiloxanes are polymers that are typically used either as an active in oral drug products or as excipients in topical and transdermal drug products. Inherent characteristics like hydrophobicity, adhesion and aesthetics allow silicones to offer function and performance to drug products. Recent technologies like swollen crosslinked silicone elastomer blend networks, sugar siloxanes, amphiphilic resin linear polymers and silicone hybrid pressure sensitive adhesives promise potential performance advantages and improved drug delivery efficacy. This article presents a review of recent silicone material developments focusing on their function as excipients influencing drug delivery in topical and transdermal systems.