Directing cell migration with asymmetric micropatterns
Directing cell migration with asymmetric micropatterns
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DOI：
10.1073/pnas.0408954102
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发表时间：
2005-01-25
影响因子：
11.1
通讯作者：
Whitesides, GM
中科院分区：
文献类型：
--
作者：
Jiang, XY;Bruzewicz, DA;Whitesides, GM
该报告表明，附着的哺乳动物细胞的极化方向决定了它们移动的方向。带有适当功能化自组装单层的微图案表面将单个细胞约束为不对称几何形状（例如，泪珠）；这些几何形状使细胞的形态极化。自组装单层的电化学解吸消除了这些限制，并允许细胞在表面上移动，它们向钝端移动。
This report shows that the direction of polarization of attached mammalian cells determines the direction in which they move. Surfaces micropatterned with appropriately functionalized self-assembled monolayers constrain individual cells to asymmetric geometries (for example, a teardrop); these geometries polarize the morphology of the cell. After electrochemical desorption of the self-assembled monolayers removes these constraints and allows the cells to move across the surface, they move toward their blunt ends.