THE ACTION OF 7 CONVULSANTS AS ANTAGONISTS OF THE GABA RESPONSE OF LIMULUS NEURONS
THE ACTION OF 7 CONVULSANTS AS ANTAGONISTS OF THE GABA RESPONSE OF LIMULUS NEURONS
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DOI：
10.1016/0306-4492(81)90083-6
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发表时间：
1981-01-01
影响因子：
3.9
通讯作者：
WALKER, RJ
中科院分区：
文献类型：
--
作者：
ROBERTS, CJ;JAMES, VA;WALKER, RJ
Intracellular recordings were made from neurons in the abdominal ganglia of L. polyphemus. GABA was inhibitory on all the neurons tested. Picrotoxinin was approximately equipotent with picrotoxin as a reversible antagonist of the GABA inhibitory response. Picrotin, the inactive component of picrotoxin, reversibly antagonized the GABA inhibitory response but was 19 times less potent than picrotoxinin. Both tert-butylbicyclophosphate and tetramethylenedisulfotetramine reversibly antagonized the GABA inhibitory responses, but were 2410 and 2705 times, respectively, less potent than picrotoxinin. Bicuculline methochloride and p-tolyl silatrane had no blocking action on the GABA inhibitory responses of these neurons.
