Hormonal responses of dairy cows with ovarian cysts to GnRH.
Hormonal responses of dairy cows with ovarian cysts to GnRH.
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卵巢囊肿奶牛对 GnRH 的激素反应。
DOI：
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发表时间：
1975
影响因子：
3.3
通讯作者：
R. S. Youngquist
中科院分区：
文献类型：
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作者：
T. Cantley;H. Garverick;C. Bierschwal;C. E. Martin;R. S. Youngquist
本研究观察了24头患卵巢囊肿者单次肌注0、50、100或250微克促性腺激素释放激素(GnRH)后的激素和临床反应。以16头正常周期哺乳奶牛为对照组。在接受GnRH治疗的18头奶牛中，有13头(72%)对治疗有反应，并在治疗后9-26天恢复发情，而接受0微克GnRH治疗的奶牛有1-6头。大多数病例可见囊性结构变得坚固，随后感觉像黄体。奶牛注射促性腺激素释放激素(GnRH)后第0天血浆黄体生成素(L H)水平显著升高。治疗有效者和无效者在治疗第0天的血浆促黄体生成素水平差异不显著。有反应的奶牛在第0天的血浆孕酮和雌二醇浓度高于无反应的奶牛(p<0.01)。在治疗后第1-13天，有反应者的黄体生成素水平低于无应答者，孕酮和雌二醇水平高于无应答者(p<0.05)。在这些天，应答者的平均血浆黄体生成素和孕酮浓度与发情后的浓度相同，或者与对照组发情后期的平均黄体生成素和孕酮浓度相同。卵巢囊肿组的平均血浆雌二醇浓度在注射当天(第0天)和治疗后1-13天高于发情周期或发情后对照组。这项研究的结果表明，患有卵巢囊肿的奶牛能够释放促黄体生成素作为对促性腺激素释放激素的反应。
A study was undertaken to observe hormonal and clinical responses of 24 cows assigned to 1 of 4 dosage groups with ovarian cysts to a single IM injection of 0 50 100 or 250 mcg of synthetic gonadotropin-releasing hormone (GnRH). 16 normally cycling lactating cows were used as the control group. Of the 18 cows receiving GnRH 13 (72%) responded to treatment and returned to estrus 9-26 days following treatment compared with 1-6 receiving 0 mcg GnRH. Increasing firmness of the cystic structures subsequently feeling like corpora lutea was noticed in most cases. A significant increase of plasma luteinizing hormone (LH) was noticed on Day 0 in cows following injection of GnRH. Difference in plasma LH on Day 0 between responders and nonresponders to treatment were insignificant. Plasma progesterone and estradiol concentrations on Day 0 were higher (p less than .01) for responding cows than for nonresponders. Lower LH concentrations were found among responders than among nonresponders on Posttreatment Days 1-13; progeste rone and estradiol concentrations were higher (p less than .05). Mean plasma LH and progesterone concentrations among responders on these days were the same as postestrous concentrations or as mean LH and progesterone concentrations in controls during the postestrous period. Mean plasma estradiol concentrations of cows with ovarian cysts were higher (p less than .005) on the injection day (Day 0) and on Days 1-13 posttreatment than during the subsequent estrous cycle or in postestrous controls. Results of this study indicate that cows with ovarian cysts are capable of releasing LH in response to GnRH.