Relationship between bone quantitative ultrasound and fractures: A meta-analysis
Relationship between bone quantitative ultrasound and fractures: A meta-analysis
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DOI：
10.1359/jbmr.060417
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发表时间：
2006-07-01
影响因子：
6.2
通讯作者：
Delgado-Rodriguez, Miguel
中科院分区：
文献类型：
--
作者：
Marin, Fernando;Gonzalez-Macias, Jesus;Delgado-Rodriguez, Miguel
简介：骨定量超声（QUS）已成为一种有前途的技术，以评估骨状态。本研究的目的是确定测量OUS与骨折的风险之间的关联。材料和方法：1985年和2005年6月之间发表的前瞻性队列研究的荟萃分析与基线测量QUS和随后的后续骨折进行。分析了14个独立的研究人群，包括约47，300人（85.4%为女性），约124，000人-年的观察和超过2350例骨折，包括653例髋关节骨折，529例前臂骨折和386例肱骨骨折。主要结果的措施是估计骨折的相对风险减少骨QUS参数1 SD以下的性别和年龄调整的平均值women.Results：11项研究评估QUS在脚跟，髌骨和指骨（两项研究）和桡骨远端（一项研究）几乎没有使用。纳入综述的研究之间无显著异质性。对于宽带超声衰减（BUA）、声速（SOS）和QUS指数/刚度指数（QUI/SI），总体骨折的相对风险估计值（95% CI）分别为1.55（1.35-1.78）、1.63（1.37-1.93）和1.74（1.39-2.17）。髋部骨折和低能量创伤骨折的风险估计相似或略高。肱骨和前臂/手腕骨折也与较低的QUS values.Conclusions：骨QUS的测量显着相关的非脊柱骨折的风险在老年妇女在一个类似的程度DXA。QUS可能是一种有效的替代方法，以评估骨折风险的情况下，DXA是不可访问的。
Introduction: Bone quantitative ultrasound (QUS) has emerged as a promising technique to evaluate bone status. The aim of this study was to determine the association between measurements of OUS with the risk of fracture.Materials and Methods: A meta-analysis of prospective cohort studies published between 1985 and June 2005 with a baseline measurement of QUS and subsequent follow-up for fractures was carried out. Fourteen separate study populations, consisting of about 47,300 individuals (85.4% women), with about 124,000 person-years of observation and over 2350 fractures, including 653 hip, 529 forearm, and 386 humeral fractures, were analyzed. The main outcome measure was the estimated relative risk of fracture for a decrease in bone QUS parameters of 1 SD below sex- and age-adjusted mean in women.Results: Eleven studies evaluated QUS at the heel, with patella and phalanx (two studies each) and distal radius (one study) being scarcely used. There was not significant heterogeneity among the studies included in the review. Relative risk estimates (95% CI) for overall fractures were 1.55 (1.35-1.78) for each SD decrease in broadband ultrasound attenuation (BUA), 1.63 (1.37-1.93) for speed of sound (SOS), and 1.74 (1.39-2.17) for QUS index/stiffness index (QUI/SI). Risk estimates were similar or slightly higher for hip fractures and low-energy trauma fractures. Humeral and forearm/wrist fractures were also related with lower QUS values.Conclusions: Measurements of bone QUS are significantly associated with nonspinal fracture risk in older women in a similar degree to DXA. QUS may be a valid alternative to evaluate fracture risk in situations where DXA is not accessible.