Dscam1 Web Server: online prediction of Dscam1 self- and hetero-affinity
Dscam1 Web Server: online prediction of Dscam1 self- and hetero-affinity
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Dscam1 Web 服务器：Dscam1 自亲和异亲和力的在线预测
DOI：
10.1093/bioinformatics/btx039
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发表时间：
2017
期刊：
影响因子：
5.8
通讯作者：
Guang-Zhong Wang
中科院分区：
文献类型：
--
作者：
Simone Marini;Nelson Nazzicari;Filippo Biscarini;Guang-Zhong Wang
Dscam 1蛋白同分异构体在细胞表面形成同源二聚体是神经突起自我回避生长的关键因素。Dscam 1蛋白的多样性在节肢动物神经元回路的形成中起着关键作用，与其他细胞表面蛋白相比，显示出独特的进化特性。实验措施可用于89个自结合和1722异源结合蛋白质样品，超过19万（自结合）和350万（异源结合）可能的异构体combinations.ResultsWe开发Dscam1 Web Server快速预测Dscam1自我和异源结合亲和力批次Dscam1异构体。该服务器可以帮助研究人员进行Dscam 1亲和力的研究，并帮助研究人员在数千万种可能的异构体组合中导航，以分离出强结合的异构体。可用性和实施Dscam 1 Web服务器可在http://bioinformatics.tecnoparco.org/Dscam1-webserver免费获得。Web服务器代码可在https://gitlab.com/ne1s0n/Dscam1-binding.Supplementary上获得信息补充数据可在Bioinformaticsonline上获得。
MotivationFormation of homodimers by identical Dscam1 protein isomers on cell surface is the key factor for the self-avoidance of growing neurites. Dscam1 immense diversity has a critical role in the formation of arthropod neuronal circuit, showing unique evolutionary properties when compared to other cell surface proteins. Experimental measures are available for 89 self-binding and 1722 hetero-binding protein samples, out of more than 19 thousands (self-binding) and 350 millions (hetero-binding) possible isomer combinations.ResultsWe developed Dscam1 Web Server to quickly predict Dscam1 self- and hetero- binding affinity for batches of Dscam1 isomers. The server can help the study of Dscam1 affinity and help researchers navigate through the tens of millions of possible isomer combinations to isolate the strong-binding ones.Availability and ImplementationDscam1 Web Server is freely available at: http://bioinformatics.tecnoparco.org/Dscam1-webserver. Web server code is available at https://gitlab.com/ne1s0n/Dscam1-binding.Supplementary informationSupplementary data are available atBioinformaticsonline.