Comorbid diseases of IgG4-related sialadenitis in the head and neck region
Comorbid diseases of IgG4-related sialadenitis in the head and neck region
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DOI：
10.1002/lary.25387
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发表时间：
2015-09-01
期刊：
影响因子：
2.6
通讯作者：
Yu, Guang-Yan
中科院分区：
文献类型：
--
作者：
Hong, Xia;Sun, Zhi-Peng;Yu, Guang-Yan
目的/假设进一步认识头颈部免疫球蛋白g4相关涎腺炎（IgG4-RS）的合并症，并观察这些疾病对免疫调节治疗的反应。研究设计：回顾性研究。方法对51例确诊为IgG4-RS的患者（男24例，女27例，中位年龄55岁）共病症状及病史进行分析。36例患者接受免疫调节治疗，随访10.45.9个月。治疗前后分别行CT检查。结果58.8%的患者出现鼻窦炎，表现为鼻塞、鼻干、低通气。此外，43.1%的患者有变应性鼻炎。74.5%的患者有淋巴结病变。泪腺肿胀发生率为78.4%。眼外肌、耳部器官、皮肤和浅表软组织、脑神经也受累。经免疫调节治疗后，所有病变均得到缓解。CT分析显示，Lund-Mackay评分从9.65.6降至1.0 +/- 2.2
Objectives/HypothesisTo further recognize the comorbid diseases of immunoglobulin G4-related sialadenitis (IgG4-RS) in the head and neck region and to observe the response of these conditions to immunomodulatory therapy.Study DesignRetrospective review.MethodsThe symptoms of comorbid diseases and medical histories in 51 patients (24 men, 27 women; median age, 55 years) diagnosed with IgG4-RS were analyzed. Thirty-six patients received immunomodulatory therapy and were followed up for 10.45.9 months. Computed tomography (CT) examination was performed before and after therapy.ResultsRhinosinusitis occurred in 58.8% patients, and manifested with the symptoms of nasal obstruction, nasal xerosis, and hyposmia. In addition, 43.1% patients had allergic rhinitis. Lymphadenopathy was identified in 74.5% patients. Lacrimal gland swelling occurred in 78.4% patients. Extraocular muscles, otologic organs, skin and superficial soft tissue, and cranial nerves were also involved. All of the lesions were relieved after immunomodulatory therapy. The Lund-Mackay scores decreased (9.65.6 to 1.0 +/- 2.2) according to CT analyses (P