Transcutaneous Cervical Vagus Nerve Stimulation Lengthens Exhalation in the Context of Traumatic Stress.
Transcutaneous Cervical Vagus Nerve Stimulation Lengthens Exhalation in the Context of Traumatic Stress.
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DOI：
10.1109/bhi50953.2021.9508534
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发表时间：
2021-07-01
期刊：
影响因子：
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通讯作者：
Inan, Omer T
中科院分区：
文献类型：
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作者：
Gazi, Asim H;Sundararaj, Srirakshaa;Inan, Omer T
迷走神经的经皮电刺激被认为将传入信号传递到大脑，这反过来又产生外周生理学的下游变化，包括心血管和呼吸参数。虽然经皮颈迷走神经刺激（tcVNS）对这些参数的影响已被广泛研究，但关于tcVNS对呼气时间和自主呼吸周期的具体影响知之甚少。通过了解这些作用，tcVNS可以用于通过对吸气和呼气的副交感神经有利的调节（特别是相对于吸气延长的呼气）来增强迷走神经张力，从而平衡痛苦后的交感神经过度活跃。因此，我们通过将呼吸周期分解为吸气和呼气时间并结合最先进的呼吸质量评估算法来研究tcVNS对呼吸计时的影响，该评估算法用于呼吸努力带和心电图衍生的呼吸信号。这使得能够仅从质量测量结果稳健地估计呼吸定时。因此，我们发现，与假手术对照组（N = 26）相比，tcVNS增加了刺激后数分钟的呼气时间。这表明，tcVNS可以抵消交感迷走神经失衡，考虑到呼气和迷走神经张力升高之间的关系。
Transcutaneous electrical stimulation of the vagus nerve is believed to deliver afferent signaling to the brain that, in turn, yields downstream changes in peripheral physiology, including cardiovascular and respiratory parameters. While the effects of transcutaneous cervical vagus nerve stimulation (tcVNS) on these parameters have been studied broadly, little is known regarding the specific effects of tcVNS on exhalation time and the spontaneous respiration cycle. By understanding such effects, tcVNS could be used to counterbalance sympathetic hyperactivity following distress by enhancing vagal tone through parasympathetically favored modulation of inspiration and expiration - specifically, lengthened expiration relative to inspiration. We thus investigated the effects of tcVNS on respiration timings by decomposing the respiration cycle into inspiration and expiration times and incorporating state-of-the-art respiration quality assessment algorithms for respiratory effort belt and electrocardiogram derived respiration signals. This enabled robust estimation of respiration timings from quality measurements alone. We thereby found that tcVNS increases expiration time minutes after stimulation, compared to a sham control (N = 26). This suggests that tcVNS could counteract sympathovagal imbalance, given the relationship between expiration and heightened vagal tone.