Structures of the Dimeric and Monomeric Chromanones, Gonytolides A-C, Isolated from the Fungus Gonytrichum sp and Their Promoting Activities of Innate Immune Responses
Structures of the Dimeric and Monomeric Chromanones, Gonytolides A-C, Isolated from the Fungus Gonytrichum sp and Their Promoting Activities of Innate Immune Responses
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DOI：
10.1021/ol2018449
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发表时间：
2011-09-02
期刊：
影响因子：
5.2
通讯作者：
Oshima, Yoshiteru
中科院分区：
文献类型：
--
作者：
Kikuchi, Haruhisa;Isobe, Masato;Oshima, Yoshiteru
先天免疫是抵御微生物感染的一线自卫。在利用果蝇体外培养系统寻找调节天然免疫的天然物质后，我们从真菌Gonitrichum sp.中鉴定出一种新的二聚体色满酮，Gonytolide A，作为一种天然免疫促进剂。与内酯B和C一样，内酯A也增加了肿瘤坏死因子-α刺激的人脐静脉内皮细胞产生IL-8。
Innate Immunity is the front line of self-defense against microbial infection. After searching for natural substances that regulate innate immunity using an ex vivo Drosophila culture system, we identified a novel dimeric chromanone, gonytolide A, as an Innate immune promoter from the fungus Gonytrichum sp. along with gonytolides B and C. Gonytolide A also increased TNF-alpha-stimulated production of IL-8 in human umbilical vein endothelial cells.