LIGHT ENHANCES SYMPATHETIC AND SUPPRESSES VAGAL OUTFLOWS AND LESIONS INCLUDING THE SUPRACHIASMATIC NUCLEUS ELIMINATE THESE CHANGES IN RATS
LIGHT ENHANCES SYMPATHETIC AND SUPPRESSES VAGAL OUTFLOWS AND LESIONS INCLUDING THE SUPRACHIASMATIC NUCLEUS ELIMINATE THESE CHANGES IN RATS
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DOI：
10.1016/0165-1838(92)90026-d
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发表时间：
1992-09-01
期刊：
影响因子：
--
通讯作者：
NAKAGAWA, H
中科院分区：
文献类型：
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作者：
NIIJIMA, A;NAGAI, K;NAKAGAWA, H
在视交叉上核（SCN）的神经元被认为是参与葡萄糖稳态的机制。通过研究光照对肾上腺、胰腺和肝脏的自主传出神经活动的影响，对这一机制进行了研究。麻醉大鼠的一只眼睛暴露于光增强肾上腺神经的传出活动，抑制迷走胰腺和肝神经。这些神经的传出活动没有变化，观察光刺激的病变，包括双边SCN的大鼠。这些结果表明，光信号调节内脏功能，包括通过视网膜下丘脑束可能通过SCN的自主传出途径支配内脏器官的代谢过程。
Neurons in the suprachiasmatic nucleus (SCN) are suggested to be involved in the mechanism of glucose homeostasis. This mechanism was examined by studies on the effect of illumination on the activity of autonomic efferents to the adrenals, pancreas and liver. Exposure of one eye of anesthetized rats to light enhanced the efferent activity of the adrenal nerve and suppressed that of vagal pancreatic and hepatic nerves. No change in efferent activities of these nerves was observed on light-stimulation of rats with lesions that included the bilateral SCN. These findings indicate that light signals modulate visceral functions including metabolic processes through the retinohypothalamic tract probably via the SCN to autonomic efferent pathways innervating visceral organs.