The roles of CD147 and/or cyclophilin A in kidney diseases.

The roles of CD147 and/or cyclophilin A in kidney diseases.
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CD147 和/或亲环蛋白 A 在肾脏疾病中的作用

DOI:
10.1155/2014/728673
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发表时间:
2014
影响因子:
4.6
通讯作者:
Zhou J
Zhou J
中科院分区:
医学3区
文献类型:
--
作者:
Qu X;Wang C;Zhang J;Qie G;Zhou J

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CD147是一种广泛表达的整体质膜糖蛋白,并与不同的伙伴结合,包括亲环蛋白、小窝蛋白-1、单羧酸转运蛋白和整合素,参与多种生理和病理活动。最近的数据表明,CyPA和CD147在肾炎症、急性肾损伤、肾纤维化和肾细胞癌中均有显著作用。在这里,我们回顾了目前对亲环蛋白A和CD147在肾脏疾病中的表达和功能的了解以及对肾脏疾病治疗的潜在影响。
CD147 is a widely expressed integral plasma membrane glycoprotein and has been involved in a variety of physiological and pathological activities in combination with different partners, including cyclophilins, caveolin-1, monocarboxylate transporters, and integrins. Recent data demonstrate that both CyPA and CD147 significantly contribute to renal inflammation, acute kidney injury, renal fibrosis, and renal cell carcinoma. Here we review the current understanding of cyclophilin A and CD147 expression and functions in kidney diseases and potential implications for treatment of kidney diseases.
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